{"id":"W3096717600","doi":"10.1182/blood-2020-137233","title":"ZUMA-4: A Phase 1/2 Multicenter Study of KTE-X19 in Pediatric and Adolescent Patients With Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Lymphoma; Mantle cell lymphoma; Internal medicine; Lymphoblastic lymphoma; Refractory (planetary science); Malignancy; Oncology; Gastroenterology; Immunology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002321219,0.001332354,0.001354622,0.000359665,0.0004522555,0.0009527875,0.001087179,0.001003723,0.003554957],"category_scores_gemma":[0.0009631252,0.0005883233,0.001074853,0.0003757625,0.0008217593,0.0008425557,0.0005205237,0.003684996,0.0009821591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001023241,"about_ca_system_score_gemma":0.002618692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097504,"about_ca_topic_score_gemma":0.003860135,"domain_scores_codex":[0.9994905,0.0002837524,0.00002096829,0.00006164414,0.00004970826,0.00009338103],"domain_scores_gemma":[0.9991508,0.0000939378,0.0001702877,0.00005696801,0.00007230547,0.0004557295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4244188,0.1570665,0.06388804,0.002606003,0.0054695,0.001574001,0.001471721,0.004943113,0.08739791,0.001326908,0.02649971,0.2233377],"study_design_scores_gemma":[0.5671239,0.3567271,0.04553442,0.0001631996,0.001701802,0.001833142,0.0003321372,0.001981401,0.006088499,0.0006826732,0.0177698,0.00006195017],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856783,0.00400884,0.0007388456,0.001175429,0.0001200771,0.003639409,0.002352263,0.0001644022,0.002122398],"genre_scores_gemma":[0.9725577,0.005086214,0.004426677,0.002406078,0.0001902988,0.006348365,0.006091763,0.00008520767,0.002807613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003554957,"threshold_uncertainty_score":0.01227587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489025329550579,"score_gpt":0.2722694317291154,"score_spread":0.2573791784336096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}