{"id":"W3096719033","doi":"10.1021/acs.jmedchem.0c01321","title":"Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and <i>in Vivo</i> Anti-Infective Activity","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Killam Trusts; National Natural Science Foundation of China; Ministry of Education of the People's Republic of China; Canada Research Chairs; State Key Laboratory of Bioreactor Engineering; Michael Smith Health Research BC; Cystic Fibrosis Canada; Ministry of Science and Technology of the People's Republic of China; Natural Science Foundation of Shanghai","keywords":"Biofilm; Microbiology; In vivo; Peptide; Chemistry; Chemokine; Proinflammatory cytokine; Antimicrobial; Lipopolysaccharide; Innate immune system; Antibiotics; Antimicrobial peptides; Bacteria; Biochemistry; Inflammation; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000983327,0.000342975,0.000118392,0.0001002371,0.00006235758,0.0001556314,0.00009120644,0.0002030905,0.0009754555],"category_scores_gemma":[0.0001176495,0.00007167254,0.00007626892,0.00007316408,0.0001256834,0.0002250478,0.0001287689,0.0002931721,0.0002183915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006369804,"about_ca_system_score_gemma":0.00007716671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000493408,"about_ca_topic_score_gemma":0.00006492426,"domain_scores_codex":[0.9999611,0.000008945654,0.000002599801,0.000009284035,0.000008167653,0.000009745279],"domain_scores_gemma":[0.9999354,0.00001250653,0.00002294166,0.000003251053,0.000006384415,0.00001953307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005617494,0.00001904417,0.00006295677,0.00004427108,0.000001587557,0.000019079,0.000003049209,0.00005341538,0.9973885,0.00003689855,0.00001787937,0.002297211],"study_design_scores_gemma":[0.00001398883,0.0009962069,0.001382028,0.000007991224,0.00000927656,0.0002452654,0.000008070946,0.0003751059,0.9946384,0.0000242378,0.002295694,0.000003780836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905827,0.002447462,0.004638052,0.00008277361,0.00003292155,0.00004251983,0.0001346803,0.00005989668,0.001979009],"genre_scores_gemma":[0.9930797,0.001167904,0.004473003,0.00007181893,0.0000146221,0.00003807286,0.00009667805,0.00001209189,0.001046084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009754555,"threshold_uncertainty_score":0.003263235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127589374062834,"score_gpt":0.2230244137229443,"score_spread":0.2117485199823159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}