{"id":"W3096724523","doi":"10.1182/blood-2020-143381","title":"A Novel Anti-Cancer Vaccine Approach for the Treatment of High-Risk Leukemia in Children","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Calgary Laboratory Services; University of Calgary","funders":"","keywords":"Leukemia; Human leukocyte antigen; Cancer; Biology; Mutation; Epitope; Computational biology; Cancer research; Immunology; Antigen; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004849354,0.0001174423,0.0001758256,0.0000132585,0.00003695722,0.000009406197,0.0001523474,0.00006548213,0.000002843719],"category_scores_gemma":[0.00001548287,0.00007434114,0.00009151221,0.00007287868,0.00001029938,0.000002554735,0.00003436903,0.00003420777,3.778922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009882465,"about_ca_system_score_gemma":0.00005119229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261736,"about_ca_topic_score_gemma":0.00000911129,"domain_scores_codex":[0.9994535,0.000007278718,0.0002027085,0.0001553847,0.0000464655,0.0001346131],"domain_scores_gemma":[0.999631,0.000008208077,0.000103891,0.0002062336,0.00002417314,0.00002645777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006619125,0.003451456,0.3122967,0.0001981135,0.003027201,2.180086e-7,0.001495754,0.02076489,0.6336309,0.0002336997,0.0008572756,0.02338194],"study_design_scores_gemma":[0.02064332,0.00211972,0.1701811,0.000008163642,0.0004633,0.00000951744,0.0002607247,0.0124672,0.7908294,0.000008806676,0.002682223,0.0003265649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916326,0.002418601,0.00512564,0.00008933098,0.00001358026,0.0005439714,0.0001381862,0.000004187048,0.00003394153],"genre_scores_gemma":[0.9930071,0.002631515,0.003775276,0.00007197314,0.000164562,0.0001323482,0.0001764354,0.00001446799,0.00002632968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1571985,"threshold_uncertainty_score":0.3031544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333932306017416,"score_gpt":0.2207824703603276,"score_spread":0.2074431473001535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}