{"id":"W3096789370","doi":"10.15252/embj.2020105164","title":"A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition","year":2020,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; Lundbeckfonden; National Institutes of Health; H. Lundbeck A/S; Novo Nordisk Fonden; Boehringer Ingelheim Fonds","keywords":"Biology; Transmembrane protein; Transmembrane domain; Transporter; Helix (gastropod); Substrate (aquarium); Amino acid; Biophysics; Membrane transport protein; Peptide sequence; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008308367,0.000297838,0.000254368,0.00008330866,0.0002206181,0.0001553496,0.0002165661,0.0004047972,0.0008395087],"category_scores_gemma":[0.0001660329,0.0001096329,0.0003333804,0.00009305955,0.0002110844,0.0002468073,0.0002743126,0.0003882469,0.0004336567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576342,"about_ca_system_score_gemma":0.0001479214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004397365,"about_ca_topic_score_gemma":0.0004075044,"domain_scores_codex":[0.9999225,0.00001336357,0.000005562038,0.00001661451,0.00002322167,0.00001865689],"domain_scores_gemma":[0.9998925,0.00001346375,0.00003343775,0.000009799931,0.00001494533,0.00003589208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458559,0.00001887249,0.0009908048,0.00006184336,0.000006306716,0.0005656454,0.0000622896,0.0003842559,0.995649,0.0003784903,0.0001119852,0.001524687],"study_design_scores_gemma":[0.00008468549,0.000814374,0.02928625,0.00003407633,0.00003611452,0.003195881,0.0001793011,0.007898172,0.9490824,0.0005560223,0.008782867,0.00004991096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994647,0.0005271847,0.00359108,0.0001176776,0.00003203166,0.00001578735,0.0001560147,0.00009393805,0.0008193653],"genre_scores_gemma":[0.9957385,0.0002492511,0.002795298,0.00007359064,0.00001269512,0.000008363279,0.0003428569,0.000008273682,0.0007711814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008395087,"threshold_uncertainty_score":0.002808392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192035363278257,"score_gpt":0.2246451321224505,"score_spread":0.2054415957946248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}