{"id":"W3096789370","doi":"10.15252/embj.2020105164","title":"A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition","year":2020,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; Lundbeckfonden; National Institutes of Health; H. Lundbeck A/S; Novo Nordisk Fonden; Boehringer Ingelheim Fonds","keywords":"Biology; Transmembrane protein; Transmembrane domain; Transporter; Helix (gastropod); Substrate (aquarium); Amino acid; Biophysics; Membrane transport protein; Peptide sequence; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252801,0.0001465502,0.0002241193,0.00003528372,0.00005015001,0.00001448038,0.0002236208,0.0001083946,0.00005593735],"category_scores_gemma":[0.00001369635,0.0001024721,0.0001592657,0.0001200419,0.00009304477,0.000008874304,0.00001293393,0.0002922479,0.000009148907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005127683,"about_ca_system_score_gemma":0.00005776104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001013946,"about_ca_topic_score_gemma":0.00002402875,"domain_scores_codex":[0.9989761,0.00007261341,0.0003860277,0.0001795221,0.0001535978,0.0002321109],"domain_scores_gemma":[0.9995352,0.000007680368,0.0001347354,0.0001346434,0.00005697083,0.0001307689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003689874,0.00005136111,0.0005542019,0.00002966293,0.00003745883,0.00004405191,0.0009717678,0.00004617727,0.9938542,0.00000382184,0.0002852773,0.003752987],"study_design_scores_gemma":[0.001878374,0.0003821505,0.01362452,0.00005061399,0.00007867985,0.000351437,0.00031023,0.0001614392,0.9793437,0.0001462857,0.003466459,0.0002061568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995702,0.001586694,0.0005957911,0.001587513,0.0001222683,0.0001183268,0.00001277515,0.000004496142,0.0002701504],"genre_scores_gemma":[0.9958124,0.002703653,0.0000949032,0.0006883932,0.0005945241,0.000005503837,0.00004143305,0.00001964141,0.00003954569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01451059,"threshold_uncertainty_score":0.4178691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192035363278257,"score_gpt":0.2246451321224505,"score_spread":0.2054415957946248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}