{"id":"W3096800089","doi":"10.1158/2159-8290.cd-20-0455","title":"Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Honorable Tina Brozman Foundation; Canadian Institutes of Health Research; V Foundation for Cancer Research","keywords":"Organoid; Biology; Cancer research; Ovarian cancer; KRAS; Immune system; Immunotherapy; Tumor microenvironment; PTEN; CRISPR; Cancer; Immunology; Gene; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Genetics; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006379219,0.0002389899,0.0004000934,0.0000461878,0.000140885,0.00008548154,0.0001007214,0.00009543,0.0001049334],"category_scores_gemma":[0.00005309768,0.0001977561,0.0001686972,0.0001800361,0.00004627477,0.0002043655,0.00003034561,0.00006976308,0.000005122115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004898931,"about_ca_system_score_gemma":0.0008842009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009556613,"about_ca_topic_score_gemma":0.0001245596,"domain_scores_codex":[0.9987137,0.000007813706,0.0002937729,0.0004562447,0.0001829555,0.0003454829],"domain_scores_gemma":[0.9992683,0.0001244638,0.0001093559,0.0001775909,0.0001855656,0.0001347073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00887732,0.001328813,0.1566566,0.0065893,0.007489686,0.00004289455,0.006325438,0.0006604879,0.04357766,0.1855352,0.05984963,0.5230669],"study_design_scores_gemma":[0.053147,0.004624105,0.2932017,0.00214577,0.004128044,0.00001950727,0.001027411,0.00441646,0.2673303,0.01192892,0.3556394,0.002391263],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6175051,0.03367525,0.1542948,0.1824156,0.002162158,0.007359897,0.001729054,0.0002449838,0.0006130441],"genre_scores_gemma":[0.972529,0.003762239,0.00843843,0.009744249,0.0009601369,0.003994917,0.0001972287,0.00008605954,0.0002877447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5206757,"threshold_uncertainty_score":0.8064258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253917803458782,"score_gpt":0.3097444191373089,"score_spread":0.2572052411027211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}