{"id":"W3096800089","doi":"10.1158/2159-8290.cd-20-0455","title":"Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Honorable Tina Brozman Foundation; Canadian Institutes of Health Research; V Foundation for Cancer Research","keywords":"Organoid; Biology; Cancer research; Ovarian cancer; KRAS; Immune system; Immunotherapy; Tumor microenvironment; PTEN; CRISPR; Cancer; Immunology; Gene; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Genetics; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159835,0.0003458168,0.0002924025,0.0005379692,0.0001508042,0.0004505992,0.0002892996,0.0004067369,0.001619825],"category_scores_gemma":[0.0001367737,0.0001658537,0.0003060146,0.0002466029,0.0002041074,0.0002702134,0.0003450359,0.0007722272,0.0005217516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002665005,"about_ca_system_score_gemma":0.0002781084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267593,"about_ca_topic_score_gemma":0.0006275181,"domain_scores_codex":[0.9998153,0.00003288179,0.00001566803,0.00003746333,0.00007106159,0.00002777636],"domain_scores_gemma":[0.9998652,0.00001924542,0.00003358202,0.0000390788,0.0000151377,0.00002775101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006653863,0.00004464667,0.0001434731,0.00004241805,0.000008580681,0.0000591475,0.00001311658,0.0004166771,0.9963611,0.0002710648,0.000128416,0.0024448],"study_design_scores_gemma":[0.00003289765,0.0005946666,0.000834907,0.00001160185,0.00003644321,0.0003543745,0.00002603153,0.001593112,0.9853718,0.0001051636,0.01103174,0.000007326875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8930135,0.005380703,0.08811294,0.0002996209,0.0002670521,0.000775647,0.00349563,0.0007554926,0.007899351],"genre_scores_gemma":[0.9626299,0.001994069,0.02866943,0.0001051024,0.00001854283,0.0004727237,0.001863135,0.0000862143,0.004160897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619825,"threshold_uncertainty_score":0.005418837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253917803458782,"score_gpt":0.3097444191373089,"score_spread":0.2572052411027211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}