{"id":"W3096812352","doi":"10.3390/cancers12113254","title":"The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Fundação para a Ciência e a Tecnologia; National Institutes of Health; Cancer Research UK","keywords":"CHEK2; Prostate cancer; Ancestor; Prostate; Medicine; Genetics; Biology; Cancer; Oncology; Internal medicine; Gene; Geography; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005417557,0.0004803322,0.0005239529,0.001123412,0.0005782383,0.0005463689,0.0003754264,0.0006201238,0.002801204],"category_scores_gemma":[0.002925364,0.0002949127,0.0007053696,0.00119111,0.0005317978,0.0002140555,0.0003873408,0.0004570015,0.0002336706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007594,"about_ca_system_score_gemma":0.000232294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003554853,"about_ca_topic_score_gemma":0.003156691,"domain_scores_codex":[0.999305,0.000195214,0.00005883659,0.0002470126,0.0001183359,0.00007558941],"domain_scores_gemma":[0.9984539,0.0004461483,0.0006882001,0.0002162559,0.00007977557,0.00011578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008737923,0.00005502854,0.9674709,0.00005158957,0.0003573235,0.003507186,0.0003833071,0.0002582334,0.01853212,0.0001143013,0.00009028152,0.008305951],"study_design_scores_gemma":[0.00003409693,0.0002200321,0.9834123,0.00001902122,0.0002397417,0.01289966,0.0001885965,0.0008835744,0.001367436,0.000166097,0.0005481991,0.00002123263],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990153,0.0001978031,0.000357795,0.00002314129,0.00000389427,0.000005783872,0.00008738939,0.000008514179,0.0003003362],"genre_scores_gemma":[0.9996334,0.00006512714,0.0001495528,0.000007491488,0.000008481006,0.000002485162,0.00005057635,0.000004169594,0.00007878287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003554853,"threshold_uncertainty_score":0.009370983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236357258392025,"score_gpt":0.2535697405692357,"score_spread":0.2412061679853154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}