{"id":"W3096812352","doi":"10.3390/cancers12113254","title":"The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Fundação para a Ciência e a Tecnologia; National Institutes of Health; Cancer Research UK","keywords":"CHEK2; Prostate cancer; Ancestor; Prostate; Medicine; Genetics; Biology; Cancer; Oncology; Internal medicine; Gene; Geography; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051308,0.0001694877,0.0001478458,0.00001062947,0.0002988894,0.00005634225,0.0001873477,0.00009360462,0.0000325135],"category_scores_gemma":[0.00008750928,0.0001256797,0.00003897909,0.0001866919,0.0002364259,0.000006220663,0.000065557,0.0001526253,0.000001777407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004622063,"about_ca_system_score_gemma":0.0009836421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004103474,"about_ca_topic_score_gemma":0.001662042,"domain_scores_codex":[0.9989865,0.00004441221,0.0001434293,0.0004037842,0.0001492415,0.0002725862],"domain_scores_gemma":[0.9993265,0.00002057897,0.0001566748,0.0002380651,0.0001157216,0.0001424721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00526359,0.00005427651,0.2393056,0.0003073874,0.005115365,0.0001399515,0.0256384,0.0322898,0.1418181,0.0001105846,0.4172969,0.1326601],"study_design_scores_gemma":[0.003005552,0.0008513814,0.02157973,0.000155625,0.0003615679,0.00002027082,0.002252662,0.006032701,0.07259595,0.00008442527,0.8920305,0.001029626],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842603,0.01006467,0.00007058106,0.003233755,0.0002578069,0.0004427157,0.001116785,0.00002963898,0.0005238091],"genre_scores_gemma":[0.9934059,0.00338384,0.00005396555,0.002110858,0.0002019472,0.0002395235,0.00006741257,0.00003663321,0.0004999672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4747336,"threshold_uncertainty_score":0.5125069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236357258392025,"score_gpt":0.2535697405692357,"score_spread":0.2412061679853154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}