{"id":"W3096881762","doi":"10.1016/j.gendis.2020.11.001","title":"Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter","year":2020,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Russian Academy of Sciences; Rīgas Tehniskā Universitāte; Rīgas Stradiņa Universitāte; Hospital for Sick Children","keywords":"Epigenetics; Mesenchymal stem cell; DNA methylation; Transfection; Biology; Adipogenesis; Cell biology; Methylation; Chromatin; Cell culture; Cellular differentiation; Stem cell; Retinoblastoma protein; Downregulation and upregulation; Molecular biology; Chemistry; Gene expression; Cell; Cell cycle; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005427744,0.0001039998,0.0001411145,0.00002007489,0.00002960703,0.000005548612,0.0000789203,0.0000710125,0.000005594168],"category_scores_gemma":[0.00001245479,0.00006855962,0.00007196802,0.0001010817,0.00006685501,0.000005090276,0.00004848389,0.00003414666,9.588295e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006683404,"about_ca_system_score_gemma":0.00005686374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008286543,"about_ca_topic_score_gemma":0.000009889189,"domain_scores_codex":[0.9992693,0.0001187081,0.0001761514,0.0002061882,0.0001275667,0.0001020932],"domain_scores_gemma":[0.9995946,0.00001259762,0.0001354713,0.0001301919,0.00007176597,0.00005540508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723831,0.00007910393,0.02592029,0.00003044301,0.00003665968,5.577556e-7,0.0005141018,0.0005794208,0.9699485,5.605775e-7,0.000006825534,0.002711095],"study_design_scores_gemma":[0.0004445312,0.0002601583,0.1358603,0.00002952757,0.00005027527,1.725935e-7,0.0002002055,0.0003221505,0.8627017,0.00001672969,0.00004045461,0.00007381965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951037,0.004029596,0.0003470822,0.00007563534,0.00002390833,0.000255629,0.0001495398,0.000002835382,0.00001203481],"genre_scores_gemma":[0.9996214,0.0002250954,0.00003946045,0.00002834913,0.00002596451,0.000009158669,0.0000310262,0.00001100222,0.000008530366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.10994,"threshold_uncertainty_score":0.279578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008739424421000378,"score_gpt":0.2046274355607893,"score_spread":0.1958880111397889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}