{"id":"W3096890632","doi":"10.1002/mds.28362","title":"Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Instituto de Salud Carlos III","keywords":"Monoamine neurotransmitter; Internal medicine; Dopaminergic; Endocrinology; Medicine; Biomarker; Pathophysiology; Dopamine; Biology; Serotonin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004952654,0.0002560989,0.0003433078,0.00006760161,0.00005596427,0.00001026642,0.00008447353,0.00004033648,0.0001230012],"category_scores_gemma":[0.0000369822,0.0002000629,0.000146369,0.0002854946,0.00006955663,0.0000822333,0.0000530423,0.0000806768,0.0000148789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004174716,"about_ca_system_score_gemma":0.0001110619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476805,"about_ca_topic_score_gemma":0.00002067752,"domain_scores_codex":[0.9986815,0.0000219536,0.000223093,0.0003958076,0.0004008904,0.0002767202],"domain_scores_gemma":[0.9990482,0.000009664623,0.0001276504,0.0002664893,0.00004830685,0.0004997287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03960349,0.02233602,0.5854497,0.004190804,0.01249934,0.0008445787,0.002005279,0.0006850547,0.2721617,0.007292651,0.004067468,0.04886398],"study_design_scores_gemma":[0.0172022,0.00109502,0.9571898,0.0002499302,0.001574936,4.591813e-7,0.0003728834,0.004349434,0.01035646,0.002121181,0.00495185,0.0005358642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98923,0.0007225804,0.004696595,0.002729306,0.00004868461,0.001574712,0.0001547138,0.00008412945,0.0007592241],"genre_scores_gemma":[0.9956217,0.00005060085,0.001479567,0.00239906,0.00001959391,0.0001579628,0.00008838897,0.00003838113,0.0001447581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3717401,"threshold_uncertainty_score":0.815833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190654389081935,"score_gpt":0.2217413174919482,"score_spread":0.2098347736011288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}