{"id":"W3096890632","doi":"10.1002/mds.28362","title":"Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Instituto de Salud Carlos III","keywords":"Monoamine neurotransmitter; Internal medicine; Dopaminergic; Endocrinology; Medicine; Biomarker; Pathophysiology; Dopamine; Biology; Serotonin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290912,0.0004385775,0.0003114657,0.0008104336,0.0002091322,0.0005044237,0.0001747098,0.0004329977,0.001548119],"category_scores_gemma":[0.0009017285,0.0001151027,0.0002707927,0.0005441043,0.000211946,0.0002666258,0.0003066331,0.0003514078,0.000320026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135715,"about_ca_system_score_gemma":0.0001100685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003071539,"about_ca_topic_score_gemma":0.0003287638,"domain_scores_codex":[0.9998081,0.00003329197,0.0000324605,0.00005909774,0.00003953874,0.00002756143],"domain_scores_gemma":[0.9992625,0.0001278842,0.0003595823,0.00002864671,0.00009459788,0.000126682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007221445,0.00006067314,0.9506944,0.00005672828,0.0001507782,0.0002947751,0.00007689842,0.0001036439,0.04151415,0.00003204924,0.0001640949,0.00612967],"study_design_scores_gemma":[0.00001116278,0.0002565335,0.9932235,0.000009841185,0.00007645047,0.001243315,0.00009403272,0.000319255,0.004398938,0.00006539536,0.0002968822,0.000004651929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982002,0.0008404745,0.0003216435,0.00003501028,0.000008746613,0.000009826787,0.0002600135,0.000008492058,0.0003156195],"genre_scores_gemma":[0.9987571,0.0001970718,0.0005420852,0.00002303366,0.00001223611,0.00001118625,0.0003092186,0.000002701722,0.000145372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548119,"threshold_uncertainty_score":0.005178928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190654389081935,"score_gpt":0.2217413174919482,"score_spread":0.2098347736011288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}