{"id":"W3096892014","doi":"10.1016/j.jpba.2020.113750","title":"Evaluation of erythropoietin biosimilars Epotin™, Hemax® and Jimaixin™ by electrophoretic methods used for doping control analysis and specific N-glycan analysis revealed structural differences from original epoetin alfa drug Eprex®","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"World Anti-Doping Agency; Agence Nationale de la Recherche","keywords":"Chemistry; Biosimilar; Glycan; Erythropoietin; Epoetin alfa; Sialic acid; Chromatography; Biochemistry; Internal medicine; Glycoprotein; Hemoglobin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004338608,0.0004079889,0.002387586,0.0008796593,0.0002049076,0.00007962013,0.0002879071,0.0003358448,0.001651731],"category_scores_gemma":[0.0007295866,0.0002684629,0.00103675,0.003346842,0.001441715,0.0000984032,0.00009836785,0.0006100296,5.273614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005171513,"about_ca_system_score_gemma":0.00008075806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006753703,"about_ca_topic_score_gemma":0.00002479337,"domain_scores_codex":[0.994376,0.002323247,0.001553869,0.0007155428,0.0005380709,0.0004932467],"domain_scores_gemma":[0.9959447,0.001977263,0.0008752461,0.0001800002,0.0005555889,0.0004672343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001667847,0.00030256,0.1473913,0.0001194316,0.09940672,0.00001189617,0.0004793016,0.00001455313,0.6872294,0.00006148736,0.001082628,0.06223291],"study_design_scores_gemma":[0.01411837,0.001742327,0.1453003,0.00008268674,0.5393411,0.00004933563,0.0009200673,0.183078,0.1058274,0.002661451,0.005708802,0.001170237],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.859702,0.02638499,0.100324,0.01267953,0.00011262,0.000284744,0.0004949105,0.00001233736,0.000004921269],"genre_scores_gemma":[0.9794896,0.002015857,0.0176891,0.0005604583,0.0001197994,0.000006355804,0.00009538131,0.00001161242,0.00001181863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.581402,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04364548467057391,"score_gpt":0.3793851311713537,"score_spread":0.3357396465007798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}