{"id":"W3096892014","doi":"10.1016/j.jpba.2020.113750","title":"Evaluation of erythropoietin biosimilars Epotin™, Hemax® and Jimaixin™ by electrophoretic methods used for doping control analysis and specific N-glycan analysis revealed structural differences from original epoetin alfa drug Eprex®","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"World Anti-Doping Agency; Agence Nationale de la Recherche","keywords":"Chemistry; Biosimilar; Glycan; Erythropoietin; Epoetin alfa; Sialic acid; Chromatography; Biochemistry; Internal medicine; Glycoprotein; Hemoglobin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004005036,0.000334284,0.0001654894,0.0002074473,0.0001526443,0.0002534996,0.0001490096,0.0003529114,0.0005417141],"category_scores_gemma":[0.0006629438,0.0001040877,0.0002226504,0.0001434607,0.0002448567,0.0002048031,0.0001826555,0.0003872311,0.00012984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823063,"about_ca_system_score_gemma":0.0001709153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003953415,"about_ca_topic_score_gemma":0.000415661,"domain_scores_codex":[0.9996241,0.00007886723,0.00002643556,0.00008068202,0.0001525738,0.00003725446],"domain_scores_gemma":[0.999769,0.00005096278,0.00006959119,0.00001862015,0.00006787444,0.00002385288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001960106,0.00004187195,0.0003358292,0.00001963444,0.000009197679,0.00004238998,0.0000404667,0.0000510808,0.9969674,0.00006064977,0.00001217972,0.002223363],"study_design_scores_gemma":[0.00001016019,0.0004885129,0.003867361,0.000004645023,0.0000272061,0.0002784818,0.00002227972,0.0005537897,0.9940919,0.00003550911,0.0006133753,0.000006631947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964195,0.0004523004,0.002331047,0.00003609129,0.00001599285,0.00001673906,0.00007019631,0.00001380402,0.0006442989],"genre_scores_gemma":[0.9952395,0.0003169561,0.003278956,0.00003821214,0.000005586229,0.00001128349,0.0001449264,0.00001065337,0.0009538247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005417141,"threshold_uncertainty_score":0.002118051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04364548467057391,"score_gpt":0.3793851311713537,"score_spread":0.3357396465007798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}