{"id":"W3096897743","doi":"10.1101/2020.10.28.359398","title":"IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"National Cancer Institute; China Medical University; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Taiwan University Hospital; Kaohsiung Medical University; Kaohsiung Chang Gung Memorial Hospital; China Medical University Hospital; Chang Gung University; National Taiwan University; Chang Gung Medical Foundation; Academia Sinica","keywords":"Cirrhosis; Hepatocellular carcinoma; Hepatitis C virus; Medicine; Genotype; Internal medicine; Allele; Immunology; Fibrosis; Gastroenterology; Virus; Oncology; Cancer research; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271835,0.0002166279,0.0001633225,0.0002042851,0.0001454437,0.0002502934,0.0001218301,0.0002279894,0.005641443],"category_scores_gemma":[0.0001534011,0.00007044359,0.0002474076,0.0001311148,0.0001696104,0.0001254214,0.0001654343,0.0003749075,0.0006545035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167163,"about_ca_system_score_gemma":0.0001691081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006515501,"about_ca_topic_score_gemma":0.00050054,"domain_scores_codex":[0.99993,0.00001854363,0.000004773442,0.00001645482,0.00001274818,0.00001739717],"domain_scores_gemma":[0.9999254,0.00001358299,0.00002611888,0.000007165821,0.00001368028,0.00001405686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001977468,0.0001825212,0.03603314,0.0003994115,0.0001136063,0.0006709137,0.00009145974,0.0004461298,0.9408112,0.0005292766,0.001601646,0.01714306],"study_design_scores_gemma":[0.0003432667,0.0008282571,0.4268093,0.0001252121,0.0002341944,0.002023973,0.0005065767,0.0054282,0.5454671,0.00245294,0.01575187,0.00002908284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887232,0.003124753,0.002718103,0.001189035,0.0001301527,0.00002511588,0.0008341949,0.0001053916,0.00315001],"genre_scores_gemma":[0.9917564,0.001073193,0.001149074,0.00017997,0.00006630543,0.00001859984,0.0006911413,0.00001436059,0.00505095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005641443,"threshold_uncertainty_score":0.01887244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778476495279603,"score_gpt":0.2686860175352271,"score_spread":0.2409012525824311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}