{"id":"W3096902844","doi":"10.1136/annrheumdis-2020-218412","title":"Switching between Janus kinase inhibitor upadacitinib and adalimumab following insufficient response: efficacy and safety in patients with rheumatoid arthritis","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Research Manitoba","funders":"Regeneron Pharmaceuticals; Genentech; Celgene; Gilead Sciences; AbbVie; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Medicine; Adalimumab; Rheumatoid arthritis; Adverse effect; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002776327,0.0004651098,0.00153777,0.0001746494,0.000237733,0.000499159,0.0003427852,0.0008103035,0.001469938],"category_scores_gemma":[0.002004748,0.0002905553,0.00102223,0.0001848861,0.0006028952,0.0004657395,0.0002442265,0.001104733,0.0002956962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880018,"about_ca_system_score_gemma":0.0005154585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003458628,"about_ca_topic_score_gemma":0.00074965,"domain_scores_codex":[0.9988606,0.0005508211,0.0001419204,0.0001486286,0.000143399,0.0001546702],"domain_scores_gemma":[0.9983216,0.0006274731,0.0005478596,0.000128466,0.00007620818,0.0002983898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8284364,0.0124863,0.02858603,0.001167511,0.001327131,0.0002564197,0.0002677668,0.0008628166,0.01297689,0.0000715759,0.0003927416,0.1131683],"study_design_scores_gemma":[0.1403001,0.781397,0.07076314,0.0001004997,0.00104565,0.0005623029,0.0001343021,0.001031211,0.003689907,0.0001041143,0.0008398478,0.00003194399],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979797,0.001575363,0.00006216015,0.00004938741,0.00002203328,0.00009581151,0.00004274218,0.000004793345,0.0001679693],"genre_scores_gemma":[0.9991543,0.0003503496,0.0001038503,0.00007559192,0.00005456081,0.0000771374,0.00006550175,8.604503e-7,0.0001177897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002776327,"threshold_uncertainty_score":0.01468277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006923661746651,"score_gpt":0.2698751059644152,"score_spread":0.2498058693469487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}