{"id":"W3096929092","doi":"10.1128/aac.01958-20","title":"Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Queen's University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Queen's University Belfast; Oxford Nanopore Technologies","keywords":"Klebsiella pneumoniae; Colistin; Lipid A; Virulence; Microbiology; Drug resistance; Bacteria; Biology; Cationic polymerization; Multiple drug resistance; Pseudomonas aeruginosa; Antibiotics; Hydroxylation; Chemistry; Biochemistry; Escherichia coli; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006468925,0.0003498448,0.0004106815,0.001365839,0.0007598026,0.001247787,0.0004234998,0.0007191158,0.0009336362],"category_scores_gemma":[0.001404135,0.0002653628,0.00032012,0.001086235,0.0007497122,0.0006235276,0.001318163,0.0006726896,0.0003231859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008023431,"about_ca_system_score_gemma":0.0005087265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001992913,"about_ca_topic_score_gemma":0.003101769,"domain_scores_codex":[0.9993538,0.0001814472,0.00003775565,0.0001617002,0.0001413867,0.0001238691],"domain_scores_gemma":[0.9992083,0.0001575947,0.0002957237,0.0000695511,0.0001370892,0.0001317647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001180247,0.0003999638,0.5716493,0.0002015695,0.000526957,0.001507537,0.002301184,0.004022289,0.3320806,0.003858454,0.000420345,0.08185163],"study_design_scores_gemma":[0.00002881081,0.0005931979,0.9756376,0.00006185698,0.00007901314,0.002761977,0.001896274,0.007550596,0.006221501,0.001572709,0.003465164,0.0001312832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997837,0.000515954,0.0007168376,0.00007134265,0.000002574168,0.00001047901,0.00004077111,0.00001015088,0.000794818],"genre_scores_gemma":[0.9977624,0.0006616543,0.0009203338,0.00004323148,0.000003967077,0.00001510715,0.0001514587,0.00001573945,0.0004259959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001992913,"threshold_uncertainty_score":0.005821407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009480201546982562,"score_gpt":0.2195212962520213,"score_spread":0.2100410947050387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}