{"id":"W3097009020","doi":"10.1182/blood-2020-136801","title":"Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Cancer research; Oxidative phosphorylation; Leukemia; Biology; Stem cell; Downregulation and upregulation; Thymocyte; Cell biology; T cell; Gene; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007909851,0.0003390711,0.0002504715,0.0002760818,0.0001159146,0.000195798,0.0001794853,0.0001187905,0.0006623318],"category_scores_gemma":[0.00003617403,0.00008138549,0.0002244482,0.0002325347,0.0001529358,0.0001362108,0.0001573209,0.0003260548,0.0001436016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497252,"about_ca_system_score_gemma":0.000178667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004302447,"about_ca_topic_score_gemma":0.0009999436,"domain_scores_codex":[0.9999477,0.000006961754,0.000003993561,0.00001104196,0.00001460421,0.00001564039],"domain_scores_gemma":[0.9999789,0.000002303027,0.000007937472,0.000002354242,0.000002914797,0.000005643049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001201217,0.00003172984,0.0003231562,0.00004104863,0.000005613961,0.00001624424,0.00000817825,0.0001813577,0.9970469,0.00006942362,0.00002841171,0.002127793],"study_design_scores_gemma":[0.00001387946,0.0007707631,0.004016793,0.000004041172,0.00002716591,0.0001197339,0.00001819234,0.0006939294,0.9924074,0.00005384305,0.001871617,0.000002727099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941192,0.001926147,0.002403551,0.0000845761,0.00001210169,0.00003998004,0.0006345149,0.00008679397,0.0006932085],"genre_scores_gemma":[0.9908789,0.003087834,0.003444136,0.00005259592,0.00000527057,0.00005470143,0.0009056522,0.00001874255,0.001552164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006623318,"threshold_uncertainty_score":0.002215683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009930602167076863,"score_gpt":0.24203639195699,"score_spread":0.2321057897899132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}