{"id":"W3097019221","doi":"10.1016/j.celrep.2020.108318","title":"A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Proteome; Transcriptome; Cell biology; Biology; RNA; Intracellular; Polyphosphate; Biochemistry; Ectopic expression; Signal transduction; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006943871,0.0002988084,0.0005338728,0.000198192,0.00009551669,0.00004441612,0.0001068125,0.0001634527,0.0005440566],"category_scores_gemma":[0.0002608354,0.0003046314,0.0001785584,0.0004834373,0.00005937554,0.0000905347,0.0001000124,0.0002518125,0.0001396476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001072913,"about_ca_system_score_gemma":0.0002080224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806912,"about_ca_topic_score_gemma":0.00003806056,"domain_scores_codex":[0.9973451,0.00008963033,0.0008906009,0.0007207945,0.0004348806,0.0005189403],"domain_scores_gemma":[0.9982976,0.00008281526,0.0002459586,0.0005982273,0.0000848675,0.0006905437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00145017,0.0003610433,0.08520806,0.0001984419,0.00003381188,0.02052077,0.004968184,0.0003297311,0.8765081,0.00002914442,0.006794198,0.003598347],"study_design_scores_gemma":[0.001561885,0.0006844993,0.0964129,0.0002068699,0.00008003496,0.0002632175,0.0002179588,0.0003809619,0.8483011,0.0001152591,0.05126326,0.0005121169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912218,0.001965363,0.0003763463,0.003143667,0.0003193452,0.0008421213,0.000002900196,0.0001897135,0.001938759],"genre_scores_gemma":[0.9855028,0.00002389951,0.0004189493,0.00241774,0.0002624017,0.00002621702,0.00003297361,0.000068081,0.01124697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04446906,"threshold_uncertainty_score":0.9999406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590890854267198,"score_gpt":0.2572103655484834,"score_spread":0.2413014570058114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}