{"id":"W3097054553","doi":"10.1182/blood-2020-141412","title":"High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of <i>Hox/Meis</i> Gene Expression in Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Hox gene; Epigenetics; Chromatin; Biology; Myeloid leukemia; Transcription factor; Cancer research; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702191,0.000447799,0.0005715294,0.000325846,0.0001325696,0.0003404273,0.0002784137,0.0002682482,0.001255762],"category_scores_gemma":[0.0001143482,0.0001633793,0.0002526221,0.0002397783,0.0001716597,0.00008242718,0.00018975,0.0003973585,0.0004153209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000380584,"about_ca_system_score_gemma":0.0002007023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009314967,"about_ca_topic_score_gemma":0.002822145,"domain_scores_codex":[0.999803,0.00002351897,0.00001848229,0.00003838827,0.00007479384,0.00004173577],"domain_scores_gemma":[0.9999224,0.00002587707,0.00001839513,0.000007000739,0.000007690509,0.00001863473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006864031,0.00003826283,0.0001748279,0.00002181496,0.000006834086,0.00004771168,0.000006471376,0.0003296017,0.9973992,0.00005626202,0.00006158125,0.001788861],"study_design_scores_gemma":[0.00002370704,0.0003379637,0.00328044,0.000003500235,0.0000225564,0.0001719671,0.00001374978,0.001990886,0.9925293,0.00002604899,0.00159344,0.000006385845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985643,0.001147301,0.007621148,0.0001387471,0.00001765951,0.0001226961,0.001770325,0.0004996955,0.003039523],"genre_scores_gemma":[0.9874999,0.0009267041,0.006887231,0.0001050244,0.000006241624,0.00008120279,0.001266278,0.00005488951,0.003172663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255762,"threshold_uncertainty_score":0.004200876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005918150406433932,"score_gpt":0.2307704639334794,"score_spread":0.2248523135270454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}