{"id":"W3097074792","doi":"10.1101/2020.11.03.366393","title":"Functional characterization of human Homeodomain-interacting protein kinases (HIPKs) in <i>Drosophila melanogaster</i> reveal both conserved functions and differential induction of HOX gene expression","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institutes of Health","keywords":"Homeotic gene; Biology; Hox gene; Drosophila melanogaster; Homeobox; Genetics; Phenotype; Phenocopy; Gene; Ectopic expression; Melanogaster; Mutant; Cell biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001887078,0.000286112,0.0003720101,0.000151772,0.00009537156,0.00002267971,0.0001196889,0.0004545484,0.00001391664],"category_scores_gemma":[0.00007370015,0.0003105585,0.00007993545,0.000142096,0.000130499,0.00001899249,0.0003165458,0.0002530109,0.000001094835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003863079,"about_ca_system_score_gemma":0.0001477539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001631869,"about_ca_topic_score_gemma":0.000003866226,"domain_scores_codex":[0.9983102,0.0001818368,0.0005613083,0.0006129081,0.00015366,0.0001800678],"domain_scores_gemma":[0.9988223,0.00001201506,0.0006261842,0.0003018196,0.0001616006,0.00007609178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002632865,0.0001123511,0.02463539,0.0002196243,0.0000716629,0.000002130497,0.000009550049,0.000009034831,0.9746338,0.00002060127,0.00001859865,0.000004050095],"study_design_scores_gemma":[0.0004457431,0.0001004038,0.3486792,0.0002289221,0.00002318902,6.593998e-8,0.000003919326,0.00000895371,0.6503066,0.000001934184,0.00003009497,0.000170979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977446,0.0001166183,0.0008947009,0.0000821116,0.0003981052,0.0005213472,0.0002186494,0.00002174736,0.000002160221],"genre_scores_gemma":[0.9989123,0.00004645247,0.0005212538,0.00001947548,0.0002673552,0.00009505882,0.00009198693,0.0000353691,0.00001070306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3243271,"threshold_uncertainty_score":0.9999347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155116275054448,"score_gpt":0.2141993441284289,"score_spread":0.1986877166229842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}