{"id":"W3097074792","doi":"10.1101/2020.11.03.366393","title":"Functional characterization of human Homeodomain-interacting protein kinases (HIPKs) in <i>Drosophila melanogaster</i> reveal both conserved functions and differential induction of HOX gene expression","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institutes of Health","keywords":"Homeotic gene; Biology; Hox gene; Drosophila melanogaster; Homeobox; Genetics; Phenotype; Phenocopy; Gene; Ectopic expression; Melanogaster; Mutant; Cell biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102673,0.000270124,0.0001086115,0.0002427933,0.0001463893,0.0002054995,0.0001516809,0.000154218,0.0006798235],"category_scores_gemma":[0.00008572995,0.0001226199,0.000278439,0.0001420843,0.0001332631,0.00008296159,0.0001167305,0.0002318121,0.0003779379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230973,"about_ca_system_score_gemma":0.0001406849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652014,"about_ca_topic_score_gemma":0.002643258,"domain_scores_codex":[0.9999219,0.000008933828,0.0000135073,0.00002009636,0.00002062257,0.00001493705],"domain_scores_gemma":[0.999911,0.00001456587,0.00003059296,0.000009928975,0.0000108114,0.00002310474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006620997,0.00001039491,0.001821427,0.00003336134,0.00001142091,0.00006687184,0.00001242722,0.00006422893,0.9967898,0.00008828859,0.00006848443,0.0009671489],"study_design_scores_gemma":[0.00002356594,0.0001700274,0.07674445,0.00001273554,0.00004736201,0.0008840869,0.00007535535,0.001553213,0.9155661,0.00007973654,0.004833623,0.000009646358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941659,0.0007930584,0.00145953,0.00007244016,0.00001414695,0.00003297481,0.002201735,0.0000380855,0.001222081],"genre_scores_gemma":[0.9879407,0.0005714337,0.003941126,0.000115617,0.000008462105,0.00003993895,0.004920214,0.00002880637,0.002433803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652014,"threshold_uncertainty_score":0.003284752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155116275054448,"score_gpt":0.2141993441284289,"score_spread":0.1986877166229842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}