{"id":"W3097082273","doi":"10.1182/blood-2020-136076","title":"Leukemia Stem Cells Demonstrate Increased DNA Damage Repair and Chemoresistance in Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Stem cell; DNA repair; Biology; RAD51; Myeloid leukemia; DNA damage; Molecular biology; Cancer research; Cell biology; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000913215,0.0002207583,0.0002326675,0.0004107604,0.000114364,0.0002173949,0.00007796659,0.0001944535,0.002227347],"category_scores_gemma":[0.00007726744,0.0001349435,0.0001345699,0.0003126069,0.0001544712,0.0001544988,0.0001690533,0.0002993169,0.0004697248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279951,"about_ca_system_score_gemma":0.00008567953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003550082,"about_ca_topic_score_gemma":0.0004224038,"domain_scores_codex":[0.9999053,0.000009244802,0.00001015755,0.00001646616,0.00004358674,0.00001511945],"domain_scores_gemma":[0.9999398,0.000008693299,0.00001824123,0.000007744089,0.000009620081,0.0000159106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379227,0.0000276541,0.003181561,0.00004275886,0.000007737819,0.00007900204,0.00003324158,0.00003636783,0.9928811,0.0001013957,0.00007552193,0.003395869],"study_design_scores_gemma":[0.00004493179,0.001065232,0.1483669,0.00001222873,0.00004213912,0.001828001,0.0001113082,0.0005147603,0.840696,0.0001705061,0.007140151,0.000007903623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941444,0.002048102,0.001885758,0.00006688768,0.000006653736,0.00003873445,0.0005086522,0.00007924739,0.00122156],"genre_scores_gemma":[0.9941043,0.00115391,0.001393329,0.00009517595,0.00001005666,0.00006101726,0.001113785,0.00001742416,0.002050998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227347,"threshold_uncertainty_score":0.007451177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571004017885232,"score_gpt":0.2455545607853131,"score_spread":0.2298445206064608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}