{"id":"W3097194532","doi":"10.1101/2020.11.02.365676","title":"Inflammatory cytokine profile and plasticity of brain and spinal microglia in response to ATP and glutamate","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University of Edmonton; Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Microglia; Glutamate receptor; Central nervous system; Neuroscience; Spinal cord; Tumor necrosis factor alpha; Neuroglia; Astrocyte; Cytokine; Spinal cord injury; Biology; Inflammation; Cell biology; Chemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177206,0.0002348347,0.0002962078,0.0002525855,0.0001479379,0.0003021306,0.0001000276,0.0003295458,0.0009282901],"category_scores_gemma":[0.0001640585,0.00008615949,0.0001664887,0.0002211525,0.000244779,0.0001808642,0.0001146539,0.0004194298,0.0002359353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376157,"about_ca_system_score_gemma":0.0001486117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000350467,"about_ca_topic_score_gemma":0.0004486183,"domain_scores_codex":[0.9998378,0.00003465424,0.00001516759,0.00002596756,0.00003688742,0.00004957548],"domain_scores_gemma":[0.9998899,0.00001879956,0.00002891427,0.000008518999,0.00002028176,0.00003363368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001022577,0.00006126583,0.0006930597,0.0000566148,0.000007138367,0.0001425884,0.00004542971,0.0000352782,0.9966066,0.0000282628,0.0000294603,0.001271809],"study_design_scores_gemma":[0.000134523,0.00443677,0.1323453,0.00006178091,0.0001069218,0.001700181,0.0005902478,0.001234635,0.8567213,0.0003109884,0.002334299,0.00002293093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963248,0.002051512,0.0005619121,0.00005100004,0.00002571352,0.000031918,0.0002458521,0.00001000293,0.0006973223],"genre_scores_gemma":[0.996986,0.0009569635,0.0007156117,0.00007967143,0.00003180167,0.00009625068,0.0002622702,0.000004951351,0.0008664734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009282901,"threshold_uncertainty_score":0.003105402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089106264253926,"score_gpt":0.2375769006241244,"score_spread":0.2166858379815851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}