{"id":"W3097196054","doi":"10.1101/2020.10.22.20217190","title":"Common and rare variants in HFE are not associated with Parkinson’s disease in Europeans","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institutes of Health; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Parkinson Canada; McGill University; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Genome-wide association study; Iron homeostasis; Parkinson's disease; Disease; Genetic association; Locus (genetics); Pathological; LRRK2; Association test; Genetics; Medicine; Biology; Single-nucleotide polymorphism; Gene; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001477908,0.0004599101,0.000953717,0.001167787,0.0007189007,0.0008930274,0.0003918852,0.0008547677,0.005883866],"category_scores_gemma":[0.004456238,0.0003089719,0.0007640444,0.001326145,0.0007274037,0.0005742325,0.000749639,0.0004020026,0.0004884599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585671,"about_ca_system_score_gemma":0.0001554404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003221964,"about_ca_topic_score_gemma":0.002421101,"domain_scores_codex":[0.9987522,0.000278834,0.0001852793,0.0005488024,0.0001293355,0.0001055709],"domain_scores_gemma":[0.9980664,0.0006895483,0.0005315288,0.0003258401,0.0001571467,0.0002296444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001922484,0.0000800511,0.976655,0.00006618065,0.001249673,0.00175556,0.0008571476,0.0003289736,0.005847511,0.0005586738,0.0006721232,0.01000666],"study_design_scores_gemma":[0.0001158035,0.0001706153,0.9933148,0.00004546477,0.0002700433,0.002787128,0.0004472455,0.000478927,0.0004193865,0.0007755569,0.001155934,0.0000191336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979218,0.0003905363,0.0004726677,0.00008178852,0.00001851274,0.000004463737,0.0003888569,0.00001017388,0.000711269],"genre_scores_gemma":[0.998985,0.0001249877,0.0001679507,0.00005777519,0.00002286401,0.000003410991,0.0003921567,0.00001093881,0.00023496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005883866,"threshold_uncertainty_score":0.01968354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05571551180667671,"score_gpt":0.263496393314253,"score_spread":0.2077808815075762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}