{"id":"W3097208588","doi":"10.1182/blood-2020-141329","title":"Fiirst-2: Prospective, Randomized Study Comparing Administration of Clotting Factor Concentrates with Standard Massive Hemorrhage Protocol in Severely Bleeding Trauma Patients","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Health Sciences Centre; Toronto General Hospital; University Health Network; University of Toronto; Defence Research and Development Canada; Sunnybrook Health Science Centre; McMaster University","funders":"","keywords":"Medicine; Clinical endpoint; Clotting factor; Interim analysis; Fresh frozen plasma; Packed red blood cells; Coagulopathy; Resuscitation; Adverse effect; Randomized controlled trial; Surgery; Blood transfusion; Internal medicine; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005827444,0.003040035,0.003678766,0.0006072544,0.0006786757,0.001613156,0.001756654,0.002695855,0.007972638],"category_scores_gemma":[0.006910629,0.0009350165,0.002624399,0.0006107903,0.001895313,0.001543227,0.0009841912,0.003347107,0.0009582183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002102413,"about_ca_system_score_gemma":0.004381157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002307695,"about_ca_topic_score_gemma":0.003975524,"domain_scores_codex":[0.9960275,0.002504645,0.0002714215,0.0005005635,0.0002982506,0.0003976384],"domain_scores_gemma":[0.9960537,0.001085159,0.00112544,0.0003966214,0.0003232425,0.001015917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9929595,0.003646206,0.0003542247,0.0001793311,0.0003720133,0.0000111665,0.00001641537,0.0001590496,0.0003069751,0.00006441965,0.0002225894,0.001708123],"study_design_scores_gemma":[0.9431939,0.05506338,0.0009083503,0.00001579922,0.0001973922,0.000009720611,0.000009632887,0.0002322934,0.00007686861,0.00007813604,0.0002041188,0.00001027725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674419,0.001291046,0.0009386219,0.0009339092,0.0006168225,0.02420817,0.001771651,0.0001163736,0.002681638],"genre_scores_gemma":[0.9439818,0.0008580116,0.0054722,0.001901016,0.000741463,0.04128835,0.002593599,0.00003007915,0.003133519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007972638,"threshold_uncertainty_score":0.03081882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449783062867522,"score_gpt":0.2864130136789199,"score_spread":0.2619151830502447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}