{"id":"W3097211158","doi":"10.1182/blood-2020-136980","title":"Early Pharmacodynamic Changes in T-Cell Activation, Proliferation, and Cytokine Production Confirm the Mode of Action of BFCR4350A, a FcRH5/CD3 T-Cell-Engaging Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Pharmacodynamics; Medicine; Aldesleukin; Cytokine; Refractory (planetary science); Antibody; Bispecific antibody; CD3; Cytokine release syndrome; Immunology; T cell; Interleukin 2; Internal medicine; Cancer research; Pharmacology; Immune system; Biology; Pharmacokinetics; Monoclonal antibody; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003620434,0.0002949273,0.0004773444,0.0001789698,0.0001297973,0.0002924569,0.0001359081,0.0002939636,0.001917655],"category_scores_gemma":[0.0005221106,0.0001238677,0.0002841013,0.0002016515,0.0001223233,0.0001688906,0.0001011711,0.0008532754,0.0004297081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030586,"about_ca_system_score_gemma":0.0002441797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006625257,"about_ca_topic_score_gemma":0.001130447,"domain_scores_codex":[0.9998038,0.0000470059,0.00001433377,0.00004079086,0.00005923189,0.00003483405],"domain_scores_gemma":[0.9997676,0.00004968446,0.00007113393,0.00002273748,0.00003446002,0.00005443962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03706694,0.002311097,0.07454211,0.0002747066,0.0003124367,0.0007561632,0.0001852602,0.001708373,0.7038427,0.0001294335,0.00291445,0.1759563],"study_design_scores_gemma":[0.002585476,0.08781935,0.6617664,0.0000464211,0.0007579337,0.003713368,0.0001193143,0.005273047,0.2236046,0.0003059947,0.01395927,0.0000488291],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992992,0.002300967,0.00110991,0.0001764587,0.00003273709,0.0001394447,0.0009037031,0.0001345994,0.002210034],"genre_scores_gemma":[0.997987,0.000199891,0.0004358458,0.0001095712,0.00001865798,0.00004141899,0.0005607229,0.000009208376,0.000637589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917655,"threshold_uncertainty_score":0.006415188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142984138194039,"score_gpt":0.2758974691287646,"score_spread":0.2544676277468242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}