{"id":"W3097233206","doi":"10.1101/gad.337287.120","title":"Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; Cancer Institute NSW; York University; Children's Medical Research","keywords":"Telomere; Biology; Telomere-binding protein; Shelterin; Telomerase; Nuclear pore; Cell biology; DNA damage; DNA replication; Genetics; Nucleoporin; DNA; Nuclear transport; Cell nucleus; DNA-binding protein; Cytoplasm; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225372,0.0003254625,0.0001894551,0.0001750432,0.00016067,0.0003735893,0.0001932773,0.0003081121,0.001697551],"category_scores_gemma":[0.0001648616,0.0001440769,0.0002300116,0.00009897457,0.0002633756,0.0003887985,0.0004175326,0.0006353466,0.0003740812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485363,"about_ca_system_score_gemma":0.0001494493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001680665,"about_ca_topic_score_gemma":0.000249878,"domain_scores_codex":[0.9998918,0.00001343972,0.000009919055,0.00003585145,0.00002651233,0.00002255461],"domain_scores_gemma":[0.9998302,0.00002230301,0.00007420517,0.00002073476,0.000009653314,0.00004273067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000483393,0.000007199728,0.0001655462,0.00001533868,0.000002634479,0.00009773274,0.00000872609,0.00002864743,0.9990427,0.00007696589,0.00002221629,0.0004838839],"study_design_scores_gemma":[0.00001345028,0.0002119249,0.008884442,0.000006386902,0.00001084089,0.001456651,0.00004784629,0.0006349176,0.9867698,0.0001520561,0.001805391,0.000006376385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940737,0.001282083,0.003335767,0.0001328933,0.00003079566,0.000009952312,0.0002325657,0.0001182048,0.0007840465],"genre_scores_gemma":[0.9982783,0.0002773307,0.0005468073,0.00002125986,0.000004859462,0.000005986088,0.0001390879,0.00001113896,0.0007152084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697551,"threshold_uncertainty_score":0.005678833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240312803306118,"score_gpt":0.2444331786614388,"score_spread":0.220401898330827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}