{"id":"W3097233206","doi":"10.1101/gad.337287.120","title":"Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; Cancer Institute NSW; York University; Children's Medical Research","keywords":"Telomere; Biology; Telomere-binding protein; Shelterin; Telomerase; Nuclear pore; Cell biology; DNA damage; DNA replication; Genetics; Nucleoporin; DNA; Nuclear transport; Cell nucleus; DNA-binding protein; Cytoplasm; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879164,0.0002176611,0.0002394654,0.00006065685,0.0002637944,0.00005425571,0.0001951829,0.00009936783,0.0001568104],"category_scores_gemma":[0.0001731375,0.0001639478,0.00004391918,0.0004690839,0.00003862614,0.00008019688,0.00008698236,0.0001293073,0.000254288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150363,"about_ca_system_score_gemma":0.0002048294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002701769,"about_ca_topic_score_gemma":0.00001286433,"domain_scores_codex":[0.9981962,0.00004836911,0.000421,0.0006006865,0.0004469298,0.0002868117],"domain_scores_gemma":[0.9988782,0.0000194331,0.0001201697,0.0004992554,0.000208217,0.0002747173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006571902,0.000326255,0.02338724,0.0003886124,0.0002203881,0.00003412138,0.01730178,0.0001328315,0.1345737,0.0004520175,0.1105693,0.7119566],"study_design_scores_gemma":[0.0006872918,0.000224107,0.04369935,0.0001214291,0.00005602434,0.00003099576,0.001494638,0.000734124,0.1206307,0.00001285569,0.8319728,0.0003356168],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442268,0.001092562,0.005382541,0.04562072,0.0003563978,0.002013716,0.00003318702,0.0004573659,0.0008167302],"genre_scores_gemma":[0.9890209,0.0002056606,0.002749791,0.006394024,0.0002309953,0.00006419481,0.0006656388,0.00005340419,0.00061541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7214035,"threshold_uncertainty_score":0.6685597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240312803306118,"score_gpt":0.2444331786614388,"score_spread":0.220401898330827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}