{"id":"W3097351189","doi":"10.3389/fmicb.2020.565158","title":"A Novel Amphibian Antimicrobial Peptide, Phylloseptin-PV1, Exhibits Effective Anti-staphylococcal Activity Without Inducing Either Hepatic or Renal Toxicity in Mice","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ocean Public Welfare Scientific Research Project; Queen's University; Queen's University Belfast","keywords":"Antimicrobial; Antimicrobial peptides; Peptide; In vivo; Candida albicans; Microbiology; In vitro; Biology; Antibiotics; Toxicity; Staphylococcus aureus; Biochemistry; Chemistry; Pharmacology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008867979,0.0004048532,0.0001559925,0.0002226602,0.00008053272,0.0001772925,0.0001450941,0.0002619961,0.0008390017],"category_scores_gemma":[0.00006771489,0.00008319696,0.0001386378,0.00009102703,0.0001682523,0.0002265914,0.00009906106,0.0004494913,0.0001764596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000121235,"about_ca_system_score_gemma":0.0001005022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291096,"about_ca_topic_score_gemma":0.0001953025,"domain_scores_codex":[0.9999588,0.000006254404,0.000002835685,0.0000097423,0.00001190432,0.00001047706],"domain_scores_gemma":[0.99993,0.000008357192,0.0000319996,0.000004462741,0.000006623693,0.00001852834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001252457,0.00003531989,0.0001876529,0.00007440132,0.000004430206,0.00006128099,0.000008723263,0.0001012305,0.9953949,0.00005048679,0.0000375665,0.003918851],"study_design_scores_gemma":[0.00003916149,0.003443424,0.006430249,0.00001404386,0.00002530743,0.0007095225,0.00002407106,0.0006230536,0.9834268,0.00005438933,0.005202798,0.000007135123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928387,0.002474722,0.002540386,0.0001224601,0.00002571314,0.00003201997,0.0003849357,0.0000663242,0.001514845],"genre_scores_gemma":[0.9910887,0.002704268,0.003342515,0.00008462851,0.00002120512,0.00003231333,0.0006090244,0.00001047394,0.002106932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008390017,"threshold_uncertainty_score":0.002806723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434207245283682,"score_gpt":0.2339772927934434,"score_spread":0.2196352203406065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}