{"id":"W3097378247","doi":"10.1182/blood-2020-136922","title":"Molecular Characterization of Clinical Response and Relapse in Patients with <i>IDH1</i>-Mutant Newly Diagnosed Acute Myeloid Leukemia Treated with Ivosidenib and Azacitidine","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myeloid leukemia; Internal medicine; IDH1; Azacitidine; Gastroenterology; Isocitrate dehydrogenase; Myeloid; Refractory (planetary science); Oncology; Biology; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004415349,0.0001914196,0.0005220277,0.000351007,0.000178487,0.0004514397,0.0002286621,0.000324348,0.0009970465],"category_scores_gemma":[0.0009172846,0.0001001645,0.0002469886,0.0002779782,0.0001714373,0.0002243543,0.0001489217,0.0004393434,0.0002502466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191409,"about_ca_system_score_gemma":0.0001857085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006369113,"about_ca_topic_score_gemma":0.0007530108,"domain_scores_codex":[0.9998094,0.00004380224,0.00002163914,0.00005503072,0.00003483208,0.00003526933],"domain_scores_gemma":[0.9994316,0.0001365557,0.0001840556,0.00002648262,0.00005798974,0.0001632552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01413983,0.0006575212,0.9231342,0.00006304221,0.0001582831,0.0005859406,0.000171529,0.0005289234,0.02669389,0.00006084843,0.0006094257,0.03319652],"study_design_scores_gemma":[0.0004405504,0.006255133,0.9857562,0.00001123803,0.0001357269,0.001947774,0.000120659,0.001063521,0.003100819,0.00004741673,0.00111063,0.00001034779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987077,0.0003674619,0.000090553,0.00003449637,0.000005717692,0.00003739018,0.000196272,0.000008023412,0.0005524739],"genre_scores_gemma":[0.9987834,0.0001108075,0.0001618479,0.00005482968,0.00001393958,0.00003948104,0.0006180172,0.000002809088,0.000214925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009970465,"threshold_uncertainty_score":0.003335416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247349235387757,"score_gpt":0.2631145687683651,"score_spread":0.2506410764144876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}