{"id":"W3097385183","doi":"10.1182/blood-2020-136677","title":"Health State Utility Valuation in Patients with Triple-Class-Exposed Relapsed and Refractory Multiple Myeloma Treated with the Bcma-Directed CAR T Cell Therapy, Idecabtagene Vicleucel (ide-cel, bb2121): Results from the Karmma Trial","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Population; Multiple myeloma; Internal medicine; Quality of life (healthcare); Chimeric antigen receptor; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001750707,0.000381243,0.0009474488,0.000233958,0.0001617708,0.0008996174,0.000264057,0.0004640945,0.00179913],"category_scores_gemma":[0.003219653,0.0001289706,0.001397666,0.000521303,0.0002164834,0.0005501311,0.0004856669,0.001025203,0.0002845348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665066,"about_ca_system_score_gemma":0.0002545631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038636,"about_ca_topic_score_gemma":0.0008659517,"domain_scores_codex":[0.9994791,0.0003083163,0.00003304864,0.00006437397,0.00005074584,0.00006440996],"domain_scores_gemma":[0.9987184,0.0004812288,0.0003844441,0.0000823214,0.00006335659,0.0002702666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1287711,0.005622899,0.7506897,0.0003269541,0.003462701,0.0002363969,0.0003476119,0.007788209,0.001848179,0.0006294462,0.004557672,0.09571909],"study_design_scores_gemma":[0.01355271,0.0520435,0.897631,0.0001248703,0.001765043,0.0005317793,0.000429077,0.02814709,0.001039813,0.002045777,0.002596758,0.00009250496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981453,0.0005647602,0.0001203612,0.0001640758,0.00001075019,0.00002090359,0.0005499102,0.000004450135,0.0004195364],"genre_scores_gemma":[0.998483,0.0001789501,0.0001155361,0.00007299436,0.00001337461,0.00003180211,0.0009894195,0.000001350222,0.0001136161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179913,"threshold_uncertainty_score":0.009258747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1646569257118793,"score_gpt":0.3122895376363006,"score_spread":0.1476326119244213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}