{"id":"W3097399323","doi":"","title":"PRE-CLINICAL STUDIES FOR THE IDENTIFICATION OF NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CNS ATYPICAL TERATOID RHABDOID TUMOR IN CHILDREN","year":2008,"lang":"en","type":"article","venue":"Archives of Disease in Childhood","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"","keywords":"Medicine; Sunitinib; Sorafenib; Cancer research; Pharmacology; Apoptosis; Irinotecan; Atypical teratoid rhabdoid tumor; Medulloblastoma; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002928759,0.0006505099,0.001056439,0.000515999,0.0004324529,0.0009612175,0.000752227,0.0007599975,0.01136368],"category_scores_gemma":[0.0021896,0.0001733363,0.0009126611,0.0005194697,0.0004456528,0.0006593959,0.0004061325,0.001420799,0.001960376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138366,"about_ca_system_score_gemma":0.002259944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007794206,"about_ca_topic_score_gemma":0.002170162,"domain_scores_codex":[0.9989777,0.0004247896,0.0001345193,0.00009041351,0.0002366076,0.0001360264],"domain_scores_gemma":[0.9975809,0.0005510927,0.0006114099,0.000134933,0.0006275833,0.0004941289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03758563,0.01171566,0.06537978,0.009853507,0.001175799,0.002691635,0.0005475583,0.002005886,0.178598,0.003441551,0.02174244,0.6652625],"study_design_scores_gemma":[0.01267914,0.2577315,0.1697279,0.002410958,0.002969275,0.01146858,0.0009633541,0.00137567,0.1537654,0.001997297,0.3847941,0.0001167241],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.627068,0.2873365,0.009474305,0.00859115,0.00130537,0.009072155,0.009095527,0.0003277901,0.0477292],"genre_scores_gemma":[0.860565,0.0860241,0.0198727,0.00413397,0.0009550621,0.005068895,0.008998161,0.000105636,0.01427647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01136368,"threshold_uncertainty_score":0.03801531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04147169164608741,"score_gpt":0.3477215208018917,"score_spread":0.3062498291558042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}