{"id":"W3097430895","doi":"10.1182/blood-2020-134236","title":"Estimation of the Impact on Treatment Costs of a Switch to Nonacog Beta Pegol (N9-GP) for the Treatment of Adults with Hemophilia B in Canada Based on Real-World Factor IX (FIX) Consumption and Clinical Outcomes Pre- and Post-Switch","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Factor IX; Medicine; Clotting factor; Bleed; Pediatrics; Internal medicine; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001228304,0.0007456527,0.0004014389,0.001719026,0.0005738474,0.001264132,0.001403577,0.0008190142,0.002304301],"category_scores_gemma":[0.006304373,0.0003605713,0.001777402,0.002363231,0.000521515,0.0006863922,0.0008502444,0.001150473,0.0001822232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03808248,"about_ca_system_score_gemma":0.01693758,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.901337,"about_ca_topic_score_gemma":0.858585,"domain_scores_codex":[0.9984736,0.0003335041,0.0001221781,0.0001617261,0.0004019199,0.0005071536],"domain_scores_gemma":[0.9943613,0.001270038,0.00195195,0.0001065376,0.001518365,0.00079177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00177965,0.0003479578,0.88842,0.0002784645,0.00111444,0.0003540809,0.0001274974,0.08897714,0.0002701548,0.001759151,0.003416382,0.01315511],"study_design_scores_gemma":[0.0002025867,0.0006135583,0.8832415,0.0002084827,0.0008737079,0.0005013293,0.001044825,0.1089951,0.0004194948,0.0006573086,0.00316572,0.00007640493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773627,0.002052453,0.0007806022,0.001182842,0.00002359238,0.0002103276,0.01503645,0.00002651931,0.003324686],"genre_scores_gemma":[0.9925697,0.0008237759,0.000659882,0.0001339925,0.00001285931,0.00004834722,0.005176612,0.000006811361,0.0005678879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09866303,"threshold_uncertainty_score":0.276309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03611974942240755,"score_gpt":0.3512765449388873,"score_spread":0.3151567955164797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}