{"id":"W3097433445","doi":"10.1101/2020.11.04.20226282","title":"Phase 1 trial of a Candidate Recombinant Virus-Like Particle Vaccine for Covid-19 Disease Produced in Plants","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); McGill University Health Centre","funders":"","keywords":"Tolerability; Medicine; Immunogenicity; Adverse effect; Vaccination; Adjuvant; Virology; Immunology; Clinical trial; Internal medicine; Pharmacology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009099498,0.001011645,0.0009605112,0.0002797113,0.0003314075,0.0005800442,0.000625226,0.001219823,0.004841043],"category_scores_gemma":[0.0003550757,0.0002901974,0.0006292387,0.0001823059,0.0004526601,0.0004297962,0.0002177663,0.002144682,0.0007728721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006667426,"about_ca_system_score_gemma":0.001140609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005713497,"about_ca_topic_score_gemma":0.001131474,"domain_scores_codex":[0.9997714,0.00007371556,0.000008928088,0.00005175666,0.00002785876,0.00006630398],"domain_scores_gemma":[0.9997626,0.00003505565,0.00005018824,0.00002571776,0.00003053238,0.00009600575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4775214,0.1171509,0.00254487,0.001054028,0.0005787446,0.0002902645,0.0002741257,0.002902082,0.3329592,0.0009948008,0.003832327,0.05989735],"study_design_scores_gemma":[0.142704,0.8316389,0.00278552,0.00003786069,0.0001694402,0.00009669505,0.00005510821,0.0008979108,0.01769651,0.0002822911,0.003620606,0.00001526938],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893216,0.0007153722,0.001220183,0.0002598629,0.0002341396,0.005597652,0.001384806,0.00009814362,0.001168246],"genre_scores_gemma":[0.977174,0.0009669788,0.003309776,0.0006245172,0.0001544371,0.007085179,0.002803358,0.00002766141,0.007853943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004841043,"threshold_uncertainty_score":0.01619488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04768316991565103,"score_gpt":0.343350181173862,"score_spread":0.295667011258211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}