{"id":"W3097471624","doi":"","title":"3D-Bioprinted Aptamer-Functionalized Bio-inks for Spatiotemporally Controlled Growth Factor Delivery","year":2020,"lang":"en","type":"article","venue":"University of Twente Research Information","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology Industry Research Assistance Council; NIHR Oxford Biomedical Research Centre; Biomedical Research Council; Agencia Estatal de Investigación; National Physical Laboratory; Japan Society for the Promotion of Science; National Medical Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; National Institutes of Health; European Regional Development Fund; Dutch Arthritis Association; Advanced Materials and Bioengineering Research; Animal Free Research UK; RWTH Aachen University; Fundação Luso-Americana para o Desenvolvimento; Öterreichisches Exzellenzzentrum für Tribologie; Engineering and Physical Sciences Research Council; Leverhulme Trust; European Commission; Universitat Jaume I; Ministry of Science and Technology, Taiwan; University of Surrey; Amt der NÖ Landesregierung; Euskal Herriko Unibertsitatea; China Scholarship Council; Ministerio de Economía y Competitividad; Arthritis Society; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; Particulate Fluids Processing Centre, University of Melbourne; Russian Foundation for Basic Research; Centro de Investigação em Materiais Cerâmicos e Compósitos; AO Foundation; National Institute for Health and Care Research; Commonwealth Scientific and Industrial Research Organisation; Newcastle University; Royal Academy of Engineering; Eusko Jaurlaritza; Dutch Arthritis Society; Inselspital, Universitätsspital Bern; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Canadian Institutes of Health Research; University of Southampton; Russian Science Foundation; Ministerio de Ciencia, Innovación y Universidades; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Agence Nationale de la Recherche; Australian Government; Agency for Science, Technology and Research; Leids Universitair Medisch Centrum; Science Foundation Ireland; Australian National Fabrication Facility; Imperial College London; National Science Foundation; Cincinnati Children's Hospital Medical Center; Cleveland State University; Royal College of Surgeons of Edinburgh; Campus France; ZonMw; Fundação para a Ciência e a Tecnologia; Bill and Melinda Gates Foundation; Monash University","keywords":"Aptamer; Self-healing hydrogels; Growth factor; Vascular endothelial growth factor; Nanotechnology; Chemistry; Tissue engineering; Nanogel; Materials science; Bioconjugation; Biophysics; Drug delivery; Biomedical engineering; Biochemistry; Biology; Molecular biology; Polymer chemistry; VEGF receptors","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007498217,0.0001095427,0.000246917,0.0004397277,0.0001655081,0.00004737243,0.0004106957,0.0001384315,0.000564196],"category_scores_gemma":[0.001384699,0.0001188631,0.0001581149,0.0004901296,0.0001911199,0.0007334035,0.0001582133,0.0003887962,0.0001826811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877881,"about_ca_system_score_gemma":0.0001471349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545677,"about_ca_topic_score_gemma":0.000005421636,"domain_scores_codex":[0.9982544,0.00008215501,0.0002910612,0.0001198882,0.0008893438,0.0003632125],"domain_scores_gemma":[0.997971,0.0004320451,0.00007763484,0.0001422611,0.001121,0.0002560766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03700427,0.0006159224,0.01734698,0.01464195,0.005064696,0.00003788127,0.02307048,0.01254477,0.06424104,0.0179662,0.3278818,0.479584],"study_design_scores_gemma":[0.01406114,0.0005273632,0.005511815,0.0001381933,0.0000308398,9.352844e-7,0.001698649,0.7108765,0.003671916,0.0001833384,0.2629481,0.0003512421],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4399595,0.0001639685,0.5246264,0.008229585,0.0004662724,0.004456317,0.000565553,0.0008513999,0.02068102],"genre_scores_gemma":[0.9940099,0.000216197,0.0051555,0.00006008913,0.00005807243,0.000004476788,0.0002122735,0.00001346293,0.000270078],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6983317,"threshold_uncertainty_score":0.617755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04862514930282179,"score_gpt":0.2694955077272919,"score_spread":0.2208703584244701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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