{"id":"W3097471624","doi":"","title":"3D-Bioprinted Aptamer-Functionalized Bio-inks for Spatiotemporally Controlled Growth Factor Delivery","year":2020,"lang":"en","type":"article","venue":"University of Twente Research Information","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology Industry Research Assistance Council; NIHR Oxford Biomedical Research Centre; Biomedical Research Council; Agencia Estatal de Investigación; National Physical Laboratory; Japan Society for the Promotion of Science; National Medical Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; National Institutes of Health; European Regional Development Fund; Dutch Arthritis Association; Advanced Materials and Bioengineering Research; Animal Free Research UK; RWTH Aachen University; Fundação Luso-Americana para o Desenvolvimento; Öterreichisches Exzellenzzentrum für Tribologie; Engineering and Physical Sciences Research Council; Leverhulme Trust; European Commission; Universitat Jaume I; Ministry of Science and Technology, Taiwan; University of Surrey; Amt der NÖ Landesregierung; Euskal Herriko Unibertsitatea; China Scholarship Council; Ministerio de Economía y Competitividad; Arthritis Society; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; Particulate Fluids Processing Centre, University of Melbourne; Russian Foundation for Basic Research; Centro de Investigação em Materiais Cerâmicos e Compósitos; AO Foundation; National Institute for Health and Care Research; Commonwealth Scientific and Industrial Research Organisation; Newcastle University; Royal Academy of Engineering; Eusko Jaurlaritza; Dutch Arthritis Society; Inselspital, Universitätsspital Bern; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Canadian Institutes of Health Research; University of Southampton; Russian Science Foundation; Ministerio de Ciencia, Innovación y Universidades; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Agence Nationale de la Recherche; Australian Government; Agency for Science, Technology and Research; Leids Universitair Medisch Centrum; Science Foundation Ireland; Australian National Fabrication Facility; Imperial College London; National Science Foundation; Cincinnati Children's Hospital Medical Center; Cleveland State University; Royal College of Surgeons of Edinburgh; Campus France; ZonMw; Fundação para a Ciência e a Tecnologia; Bill and Melinda Gates Foundation; Monash University","keywords":"Aptamer; Self-healing hydrogels; Growth factor; Vascular endothelial growth factor; Nanotechnology; Chemistry; Tissue engineering; Nanogel; Materials science; Bioconjugation; Biophysics; Drug delivery; Biomedical engineering; Biochemistry; Biology; Molecular biology; Polymer chemistry; VEGF receptors","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763011,0.0003561236,0.000186221,0.0003254256,0.0001189848,0.0003470583,0.0002824859,0.0004806267,0.001192822],"category_scores_gemma":[0.0002897034,0.0002292628,0.0002425719,0.0001764161,0.0002623101,0.0002958017,0.0001628329,0.0003356469,0.0006915356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078508,"about_ca_system_score_gemma":0.0001252953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000184839,"about_ca_topic_score_gemma":0.0002531062,"domain_scores_codex":[0.9997999,0.00001707747,0.00002254054,0.00005667652,0.00007446892,0.00002937607],"domain_scores_gemma":[0.9997846,0.00007576768,0.00005892954,0.00003160359,0.00002884967,0.00002032699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001385167,0.00000907558,0.00003877345,0.00004518633,0.000001980651,0.00005531327,0.00002057501,0.0003164942,0.9973953,0.0001074183,0.00003964323,0.001956337],"study_design_scores_gemma":[0.000001251222,0.00001519743,0.0001132606,0.000001387632,0.00000176387,0.00005011058,0.00000202446,0.0008989617,0.9981261,0.00001688248,0.0007694904,0.000003504558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9154119,0.003804251,0.07242589,0.0001676595,0.0001896938,0.00008618315,0.0005027784,0.001287115,0.006124604],"genre_scores_gemma":[0.9409402,0.001281232,0.05091617,0.00007489276,0.00002768589,0.00009812092,0.0002350739,0.0001602496,0.006266375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192822,"threshold_uncertainty_score":0.003990352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04862514930282179,"score_gpt":0.2694955077272919,"score_spread":0.2208703584244701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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