{"id":"W3097477684","doi":"10.3390/cancers12113134","title":"Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Fundação de Amparo à Pesquisa do Estado de São Paulo; CHILDREN with CANCER UK","keywords":"Acute promyelocytic leukemia; Arsenic trioxide; Cancer research; Promyelocytic leukemia protein; Leukemia; Medicine; Tretinoin; Gene knockdown; Nicotinamide phosphoribosyltransferase; Stem cell; Cell growth; Retinoic acid; Apoptosis; Immunology; Biology; Cell culture; Cell biology; NAD+ kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009084804,0.0001556547,0.0001740821,0.00002356706,0.00005131331,0.0000289478,0.0001115819,0.0001377842,0.000007333378],"category_scores_gemma":[0.00009672134,0.0001436191,0.00002786799,0.0002102956,0.00007926916,0.000008167525,0.00002859608,0.0001311787,0.000001459152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004540379,"about_ca_system_score_gemma":0.001527734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003105773,"about_ca_topic_score_gemma":0.0001013352,"domain_scores_codex":[0.9990169,0.00005383153,0.0001799332,0.0004130491,0.000124852,0.0002114212],"domain_scores_gemma":[0.999559,0.00001005708,0.0001083096,0.0001509348,0.00006664352,0.0001050263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008717524,0.000009102648,0.003241711,0.000144467,0.00008483114,0.00003743483,0.0008332622,0.0001478359,0.991994,0.00001095135,0.00243727,0.0001873318],"study_design_scores_gemma":[0.002447112,0.0003121012,0.001261077,0.00008120259,0.00005950777,0.000004259259,0.0001616271,0.0006873476,0.9921649,0.00003592388,0.002488987,0.0002959553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968571,0.001338508,0.0001209183,0.0002044194,0.00002160563,0.0002989555,0.0000159789,0.0000165852,0.001125946],"genre_scores_gemma":[0.9976326,0.0003356168,0.0003019855,0.0008643331,0.00006921996,0.00006706774,0.00008910304,0.00002373674,0.0006163234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980635,"threshold_uncertainty_score":0.5856615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007513091923975861,"score_gpt":0.2150612136818998,"score_spread":0.2075481217579239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}