{"id":"W3097477684","doi":"10.3390/cancers12113134","title":"Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Fundação de Amparo à Pesquisa do Estado de São Paulo; CHILDREN with CANCER UK","keywords":"Acute promyelocytic leukemia; Arsenic trioxide; Cancer research; Promyelocytic leukemia protein; Leukemia; Medicine; Tretinoin; Gene knockdown; Nicotinamide phosphoribosyltransferase; Stem cell; Cell growth; Retinoic acid; Apoptosis; Immunology; Biology; Cell culture; Cell biology; NAD+ kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445516,0.0001657357,0.0002437113,0.0004886274,0.0001159031,0.0002944775,0.00009733847,0.0001958487,0.001254112],"category_scores_gemma":[0.0002652627,0.0001123443,0.0001916508,0.0003768358,0.0001850369,0.0001068598,0.0001556984,0.0002946724,0.0001783296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001093171,"about_ca_system_score_gemma":0.0001054637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610482,"about_ca_topic_score_gemma":0.0002734199,"domain_scores_codex":[0.9998915,0.00002362377,0.0000129521,0.00002332504,0.00003218343,0.00001632773],"domain_scores_gemma":[0.9996846,0.0000421576,0.0001747922,0.00002448715,0.00002094253,0.00005300299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002867196,0.0001017469,0.1818899,0.0001223495,0.000135898,0.002263397,0.0001228265,0.0003384725,0.8012941,0.000157943,0.0002761451,0.01042997],"study_design_scores_gemma":[0.00005292481,0.0007408896,0.9239051,0.0000114819,0.0001263879,0.009585403,0.0001376578,0.001316779,0.06209993,0.0001680201,0.001843901,0.00001138133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998914,0.0004526185,0.0002891302,0.00001832516,0.000001858163,0.000002923864,0.000143633,0.00002400527,0.0001534468],"genre_scores_gemma":[0.9991504,0.0002139989,0.0001438197,0.000013777,0.000004570926,0.000004869871,0.0002128266,0.000004067443,0.0002517814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254112,"threshold_uncertainty_score":0.004195392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007513091923975861,"score_gpt":0.2150612136818998,"score_spread":0.2075481217579239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}