{"id":"W3097486607","doi":"10.1182/blood-2020-137658","title":"<i>TET2</i> and <i>DNMT3A</i> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; DNA repair; Epigenetics; DNA methylation; Mutation; DNA damage; Ku80; Cancer research; Homologous recombination; Haematopoiesis; Genetics; DNA; Molecular biology; Cell biology; Gene; Stem cell; DNA-binding protein; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081612,0.0002445469,0.0002768211,0.0002297432,0.00009116114,0.0002855754,0.000179877,0.0002650771,0.001777418],"category_scores_gemma":[0.0001318949,0.0001447159,0.0003314587,0.0001769527,0.0001083222,0.0001315161,0.0001776735,0.000578297,0.000464677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334675,"about_ca_system_score_gemma":0.0001140454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007066001,"about_ca_topic_score_gemma":0.0007681026,"domain_scores_codex":[0.999808,0.00001911921,0.00002411233,0.00003671506,0.00006599037,0.00004611358],"domain_scores_gemma":[0.9998763,0.00001600427,0.00003284593,0.00002056234,0.00001399601,0.00004027912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054266,0.00002541821,0.0005129339,0.00001524172,0.0000103092,0.0000261511,0.000006993042,0.00006106176,0.9970073,0.00005327472,0.00009270891,0.002083085],"study_design_scores_gemma":[0.00002961889,0.0007870722,0.04343345,0.000007983806,0.00003814605,0.0008203914,0.00003701878,0.0007209104,0.9491162,0.00007269988,0.004929574,0.00000684039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929389,0.002037174,0.0009218319,0.00009771215,0.00002148991,0.00002187621,0.001003484,0.0001177081,0.002839751],"genre_scores_gemma":[0.9945299,0.0008639977,0.0005563768,0.00009247996,0.000005387848,0.00003112129,0.001552552,0.00002354395,0.002344647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777418,"threshold_uncertainty_score":0.00594604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006196082563575432,"score_gpt":0.2083175268363363,"score_spread":0.2021214442727609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}