{"id":"W3097493469","doi":"10.1182/blood-2020-139948","title":"Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Medicine; Tolerability; Hemodialysis; Hemostasis; Placebo; End stage renal disease; Internal medicine; Adverse effect; Surgery; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001370724,0.001226561,0.002520379,0.0003028937,0.0004017634,0.0008381958,0.000726019,0.001698626,0.004212288],"category_scores_gemma":[0.001274456,0.0005358799,0.001131583,0.0003930659,0.0007556112,0.0007320756,0.0002457368,0.001577452,0.0005399313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004308819,"about_ca_system_score_gemma":0.00106131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097453,"about_ca_topic_score_gemma":0.0009767383,"domain_scores_codex":[0.9995154,0.0002558005,0.00003788728,0.00009091546,0.00003999878,0.00005999531],"domain_scores_gemma":[0.9991512,0.0002402473,0.0002295529,0.00005403464,0.00007667701,0.000248214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9725184,0.008512139,0.0009730679,0.0005152548,0.0005498248,0.00003708043,0.00003813004,0.0001369894,0.003357789,0.00004412617,0.0004483347,0.01286895],"study_design_scores_gemma":[0.9072313,0.08936566,0.002121556,0.00001776478,0.0002330968,0.00002825227,0.00001179318,0.0002464041,0.0003644098,0.00004168432,0.0003289657,0.00000913851],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915984,0.003590199,0.0004365013,0.0003057627,0.0002167172,0.002276946,0.0006036933,0.00007888659,0.0008929552],"genre_scores_gemma":[0.9899787,0.002194052,0.001264629,0.0007671063,0.0004400972,0.003298676,0.0006475093,0.00001449808,0.001394646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004212288,"threshold_uncertainty_score":0.01409149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513353598757884,"score_gpt":0.2586536295797788,"score_spread":0.2435200935921999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}