{"id":"W3097496716","doi":"10.1182/blood-2020-137303","title":"Once Weekly Selinexor, Bortezomib, and Dexamethasone Versus Twice Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Age and Frailty Subgroup Analyses from the Phase 3 Boston Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary; University of Alberta","funders":"","keywords":"Bortezomib; Dexamethasone; Multiple myeloma; Medicine; Internal medicine; Oncology; Refractory (planetary science); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003321915,0.0009907981,0.00210929,0.0005442366,0.0002539142,0.0007520166,0.0006616234,0.0007962556,0.002365804],"category_scores_gemma":[0.002145508,0.0003543205,0.005364327,0.0005501712,0.0003018067,0.0004611504,0.0006242534,0.001210537,0.0002485202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005614533,"about_ca_system_score_gemma":0.0006289947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001702314,"about_ca_topic_score_gemma":0.004565706,"domain_scores_codex":[0.9988128,0.0006518025,0.0001353763,0.0001665787,0.0001076408,0.0001257848],"domain_scores_gemma":[0.9985454,0.000435169,0.0004758809,0.000193016,0.00007782109,0.0002726263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8464941,0.001620125,0.08845637,0.0006073966,0.02817148,0.0001489147,0.0001697443,0.001546078,0.004572334,0.0001132073,0.002132781,0.02596744],"study_design_scores_gemma":[0.3236516,0.1487444,0.4505657,0.0002852514,0.0583015,0.0005659738,0.0004356011,0.006629091,0.002598791,0.001142521,0.006943081,0.0001366009],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992455,0.004842983,0.0002266487,0.0002151422,0.0000699938,0.0003078045,0.001369143,0.00001863112,0.0004946988],"genre_scores_gemma":[0.9959471,0.0008126252,0.0003036544,0.000338243,0.0001136933,0.0004427091,0.001521204,0.000009099572,0.0005117302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003321915,"threshold_uncertainty_score":0.01756817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1543270566202218,"score_gpt":0.3934805609807746,"score_spread":0.2391535043605528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}