{"id":"W3097533843","doi":"10.1182/blood-2020-134948","title":"Personalized Targeted Radioimmunotherapy with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] in Patients with Active Relapsed or Refractory Acute Myeloid Leukemia Results in Successful Donor Hematopoietic Cells Engraftment with the Timing of Engraftment Not Related to the Radiation Dose Delivered","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Radioimmunotherapy; Medicine; Haematopoiesis; Myeloid leukemia; Refractory (planetary science); Myeloid; Cancer research; Leukemia; Internal medicine; Stem cell; Oncology; Immunology; Antibody; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917784,0.0002165344,0.0003781603,0.0001282683,0.0001711839,0.0002317936,0.0001472257,0.0001849083,0.001177659],"category_scores_gemma":[0.0001386566,0.00009253418,0.0002819771,0.0001435921,0.000161932,0.0001231275,0.0001283109,0.000239606,0.0002940099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232752,"about_ca_system_score_gemma":0.0002284914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002353574,"about_ca_topic_score_gemma":0.00075667,"domain_scores_codex":[0.9999424,0.0000120703,0.000005217985,0.00001421735,0.000006948783,0.00001916192],"domain_scores_gemma":[0.9999428,0.000009309443,0.00001498205,0.000004291204,0.000001698792,0.00002692513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1003265,0.01692693,0.324249,0.0009152265,0.0006393486,0.003231549,0.0004232233,0.003782526,0.1878867,0.0007384651,0.00550258,0.3553779],"study_design_scores_gemma":[0.01787839,0.1631577,0.7709481,0.0001472633,0.0008389212,0.007645676,0.0001973312,0.002468835,0.02017354,0.0003636843,0.01614095,0.00003967508],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975217,0.001046931,0.000281412,0.00004705029,0.00001264028,0.0001250101,0.0001098697,0.00001889838,0.0008365162],"genre_scores_gemma":[0.9984419,0.0004579326,0.0003059094,0.0001307614,0.00002773953,0.00008561212,0.0002118549,0.000001761943,0.0003366487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177659,"threshold_uncertainty_score":0.003939688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175197568345844,"score_gpt":0.2494148558218979,"score_spread":0.2376628801384395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}