{"id":"W3097541913","doi":"10.1002/jms.4675","title":"Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry","year":2020,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Bundesministerium für Bildung und Forschung","keywords":"Chemistry; Umbelliferone; Tandem mass spectrometry; Chromatography; Mass spectrometry; Selected reaction monitoring; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007889788,0.0003124232,0.001286795,0.001168745,0.00006489913,0.00006105429,0.0002987163,0.0001782788,0.0002779947],"category_scores_gemma":[0.002247214,0.0002777004,0.0003282369,0.001803101,0.000179953,0.0002632739,0.00006519354,0.0008128888,0.000001757234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194279,"about_ca_system_score_gemma":0.0003764845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002021399,"about_ca_topic_score_gemma":0.000003511572,"domain_scores_codex":[0.9967061,0.0001352604,0.001218979,0.0003552555,0.001004556,0.0005798941],"domain_scores_gemma":[0.9972872,0.001033502,0.0006946094,0.0002033806,0.0003153119,0.0004659812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007602896,0.0004243301,0.4889653,0.0006214959,0.0003721841,0.0005034031,0.0001640713,0.00001823656,0.507756,0.0001288296,0.00008158776,0.000204278],"study_design_scores_gemma":[0.01287864,0.006519571,0.3915669,0.0005982696,0.0008199469,0.0006588884,0.001700399,0.001372724,0.5815066,0.001895567,0.00005005012,0.0004324231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902626,0.005911582,0.001311078,0.001603572,0.0001379306,0.0005263448,0.00002314253,0.0000155,0.0002082672],"genre_scores_gemma":[0.9661263,0.0008182872,0.03238489,0.0001682931,0.0004253546,0.00000554605,0.000003090065,0.00005687322,0.00001133899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09739836,"threshold_uncertainty_score":0.9999675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04051854199946697,"score_gpt":0.3034329084169322,"score_spread":0.2629143664174652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}