{"id":"W3097577984","doi":"10.1182/blood-2020-137582","title":"Reduction in Absolute Involved Free Light Chain and Difference between Involved and Uninvolved Free Light Chain Is Associated with Prolonged Major Organ Deterioration Progression-Free Survival in Patients with Newly Diagnosed AL Amyloidosis Receiving Bortezomib, Cyclophosphamide, and Dexamethasone with or without Daratumumab: Results from Andromeda","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"AL amyloidosis; Immunoglobulin light chain; Progression-free survival; Medicine; Internal medicine; Multiple myeloma; Amyloidosis; Cyclophosphamide; Gastroenterology; Bortezomib; Dexamethasone; Immunology; Chemotherapy; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001821371,0.000534739,0.0008311856,0.0002592413,0.0002185388,0.0007956378,0.0003711078,0.0004160245,0.00136455],"category_scores_gemma":[0.001078912,0.0001894421,0.001520778,0.0003631401,0.0003709465,0.0003997402,0.000392483,0.001477405,0.0002031761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004641785,"about_ca_system_score_gemma":0.0007082897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004373986,"about_ca_topic_score_gemma":0.001534045,"domain_scores_codex":[0.9993974,0.0002461532,0.00006090345,0.0001119603,0.0001158183,0.00006778401],"domain_scores_gemma":[0.9982907,0.000399432,0.0005649809,0.0001187834,0.00012003,0.0005058883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4440228,0.007262969,0.4126896,0.001248749,0.005061587,0.0002962388,0.0003020189,0.002038804,0.02407552,0.0002680664,0.002103565,0.1006301],"study_design_scores_gemma":[0.04769871,0.1453729,0.786124,0.0002169667,0.005234749,0.001182529,0.0001843545,0.001928496,0.00569693,0.000360847,0.00590949,0.00009005754],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945111,0.003667284,0.0001319671,0.0001157948,0.0000371392,0.0001088107,0.0006589151,0.00001269293,0.0007562688],"genre_scores_gemma":[0.9972032,0.0006204238,0.0003397433,0.0001821315,0.00007352087,0.00008094541,0.001169637,0.000004680119,0.0003258705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821371,"threshold_uncertainty_score":0.009632409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157157194273371,"score_gpt":0.2221743407372568,"score_spread":0.2106027687945231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}