{"id":"W3097594063","doi":"10.3389/fcell.2020.599472","title":"PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Universitair Ziekenhuis Gent; Stichting Villa Joep; Vlaamse regering; National Center for Research Resources; Fonds Wetenschappelijk Onderzoek; Agentschap voor Innovatie door Wetenschap en Technologie; Stichting Tegen Kanker; Universiteit Gent; National Cancer Institute; University of Toronto; Kom op tegen Kanker; Alex's Lemonade Stand Foundation for Childhood Cancer; American Cancer Society","keywords":"Haematopoiesis; Biology; Stem cell; Progenitor cell; Cellular differentiation; Cell biology; Zebrafish; Lymphopoiesis; Cord blood; Hematopoietic stem cell; Epigenetics; Gene knockdown; Progenitor; Regulator; Blood cell; CD34; Immunology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190647,0.0001529431,0.0001363847,0.0001897936,0.0001042678,0.0002064701,0.00008839677,0.0002097781,0.002023848],"category_scores_gemma":[0.0001101593,0.00006318212,0.000138408,0.00009998045,0.0001610367,0.000102502,0.0001483531,0.0003518112,0.0002561632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837162,"about_ca_system_score_gemma":0.0001700898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009855616,"about_ca_topic_score_gemma":0.0009485626,"domain_scores_codex":[0.9998802,0.00001372093,0.00001126294,0.00003124136,0.00003739972,0.00002617006],"domain_scores_gemma":[0.999956,0.00001140879,0.000009216185,0.000005226114,0.000005809865,0.00001228951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237242,0.00002014175,0.0004577636,0.00003047286,0.000004251963,0.00003000634,0.00001797012,0.00008687701,0.9966011,0.00007121027,0.00006059321,0.002495931],"study_design_scores_gemma":[0.000005974599,0.0001875945,0.00446552,0.000002860519,0.0000156541,0.0001206197,0.00002554422,0.0003789138,0.9925499,0.00003867627,0.002205599,0.000003233405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937726,0.001743054,0.001656223,0.0001127519,0.00002512753,0.00002331273,0.0009386939,0.00008058366,0.001647778],"genre_scores_gemma":[0.9955313,0.0007319247,0.0009539119,0.00004031972,0.000004294888,0.00001524259,0.0006937392,0.00001469894,0.002014644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023848,"threshold_uncertainty_score":0.006770432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679142433164001,"score_gpt":0.2484039915685095,"score_spread":0.2316125672368694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}