{"id":"W3097655634","doi":"10.1182/blood-2020-135868","title":"Safety and Efficacy of Idasanutlin in Patients (pts) with Hydroxyurea (HU)-Resistant/Intolerant Polycythemia Vera (PV): Results of an International Phase II Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Polycythemia vera; Medicine; Internal medicine; Maximum tolerated dose; Phases of clinical research; Gastroenterology; Adverse effect; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009988101,0.0005877799,0.001391805,0.0002815172,0.0002266713,0.0007920883,0.0004175554,0.000644498,0.001359735],"category_scores_gemma":[0.0008862776,0.0002329323,0.0009500192,0.0003664466,0.0004632734,0.0005380266,0.0002212796,0.001531866,0.0003219521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005241375,"about_ca_system_score_gemma":0.0005227624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000290137,"about_ca_topic_score_gemma":0.0006227808,"domain_scores_codex":[0.999655,0.0001728399,0.00003404464,0.00007014988,0.00003443137,0.00003352502],"domain_scores_gemma":[0.999403,0.0001286371,0.0001655726,0.00004817509,0.00003929264,0.0002153243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5886704,0.02321342,0.04612716,0.002140059,0.003791387,0.0007426188,0.0005305096,0.003056598,0.0779947,0.0003871882,0.005122069,0.2482239],"study_design_scores_gemma":[0.3170205,0.5577216,0.09672079,0.0002293872,0.003287624,0.001794635,0.0002080587,0.002649514,0.009709653,0.0004034607,0.01017645,0.00007830891],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867678,0.008055327,0.0006213463,0.0003119734,0.00006865242,0.001047773,0.001036691,0.00006092497,0.002029538],"genre_scores_gemma":[0.9934341,0.002425818,0.0009512213,0.0005418301,0.00008377008,0.0006109516,0.001418408,0.00001455653,0.000519477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391805,"threshold_uncertainty_score":0.005282283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291954995246105,"score_gpt":0.2745294814535199,"score_spread":0.2616099315010589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}