{"id":"W3097688140","doi":"10.1039/d0sc03509b","title":"Single-nucleotide resolution of <i>N</i><sup>6</sup>-adenine methylation sites in DNA and RNA by nitrite sequencing","year":2020,"lang":"en","type":"article","venue":"Chemical Science","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation; York University","keywords":"Deamination; DNA; Guanine; RNA; CpG site; Chemistry; Nucleic acid; Hypoxanthine; DNA methylation; Nucleotide; Methylation; Biochemistry; Molecular biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638204,0.00006355248,0.00007873703,0.00002268395,0.00003888009,0.0000176291,0.0001427882,0.0000520968,0.0000047539],"category_scores_gemma":[0.0002155397,0.00006127402,0.00001838158,0.0003314663,0.00028225,0.00001479705,0.00007562458,0.0000553114,8.786228e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003466595,"about_ca_system_score_gemma":0.00004980235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002257031,"about_ca_topic_score_gemma":0.000001209013,"domain_scores_codex":[0.9992703,0.00001365865,0.0001541552,0.0002872826,0.0001328028,0.0001417667],"domain_scores_gemma":[0.9996852,0.00001037256,0.00005356721,0.0001103022,0.0000565095,0.00008400294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001470716,0.0000111409,0.0004588262,0.000008526036,0.000001228757,1.778718e-7,0.0001143311,0.00007774853,0.9970522,0.00001659866,0.0002127925,0.002031753],"study_design_scores_gemma":[0.0001644645,0.00004477443,0.0001305519,0.000009020596,0.000003074861,0.000001105821,0.00007815473,0.005544438,0.9928436,0.0000459851,0.001061209,0.00007358226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975498,0.0007656608,0.0006483452,0.0005005784,0.000007960171,0.0000632165,0.000008502584,0.000005390344,0.0004505492],"genre_scores_gemma":[0.9988683,0.00006825492,0.0007922802,0.0001693594,0.0000542244,0.0000039897,0.00002224969,0.000004285737,0.00001708329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00546669,"threshold_uncertainty_score":0.2498682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239096244186098,"score_gpt":0.2486173129482627,"score_spread":0.2247076885296529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}