{"id":"W3097688140","doi":"10.1039/d0sc03509b","title":"Single-nucleotide resolution of <i>N</i><sup>6</sup>-adenine methylation sites in DNA and RNA by nitrite sequencing","year":2020,"lang":"en","type":"article","venue":"Chemical Science","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation; York University","keywords":"Deamination; DNA; Guanine; RNA; CpG site; Chemistry; Nucleic acid; Hypoxanthine; DNA methylation; Nucleotide; Methylation; Biochemistry; Molecular biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003677883,0.0003157348,0.0002600736,0.000154166,0.0002104855,0.0002271291,0.0003711527,0.0004527986,0.001072919],"category_scores_gemma":[0.000787135,0.0002379432,0.0001882652,0.0001545649,0.0003447357,0.0003039159,0.0002354432,0.0006382646,0.0006352191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572673,"about_ca_system_score_gemma":0.0002476672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004802268,"about_ca_topic_score_gemma":0.001327952,"domain_scores_codex":[0.9998531,0.00003231357,0.000007527637,0.00004020707,0.00005155979,0.00001524666],"domain_scores_gemma":[0.9996338,0.0001132436,0.00007181575,0.00005684242,0.00008858417,0.000035688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004510628,0.000003715442,0.0001677981,0.00001761884,0.000001666757,0.00002482222,0.00002402509,0.00009443233,0.9978526,0.0001882866,0.00003906558,0.001540945],"study_design_scores_gemma":[0.000002117855,0.0000546913,0.0005393579,0.000003225825,0.000002413505,0.00006629086,0.00001506358,0.0006513945,0.9971761,0.0001544176,0.001331139,0.000003899635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8913659,0.001086062,0.09882139,0.0002815055,0.00009791642,0.00007534013,0.0009811259,0.0005082965,0.006782537],"genre_scores_gemma":[0.8699724,0.001204229,0.1178262,0.0001550627,0.00001652072,0.0001475315,0.001309325,0.0002348625,0.009133836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072919,"threshold_uncertainty_score":0.003589272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239096244186098,"score_gpt":0.2486173129482627,"score_spread":0.2247076885296529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}