{"id":"W3097739517","doi":"10.2337/db19-1050","title":"Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Juvenile Diabetes Research Foundation United Kingdom","keywords":"Proinsulin; Cytotoxic T cell; CD8; T cell; Lymph node stromal cell; Antigen-presenting cell; Major histocompatibility complex; NOD mice; Biology; Cell biology; CD28; MHC class I; Immunology; Antigen; Immune system; Diabetes mellitus; Endocrinology; Autoimmunity; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373537,0.0003411339,0.0001669093,0.0001926942,0.00008300297,0.0002477352,0.0001391284,0.0001564638,0.001137525],"category_scores_gemma":[0.00006766647,0.00008884017,0.0001764597,0.0001121066,0.0001916472,0.0001517238,0.0001677925,0.0005979756,0.0004203582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395273,"about_ca_system_score_gemma":0.0001288482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001523279,"about_ca_topic_score_gemma":0.0003592457,"domain_scores_codex":[0.9998851,0.00002326511,0.0000135306,0.00002261459,0.00002908826,0.00002635365],"domain_scores_gemma":[0.999896,0.00001400001,0.00002575376,0.00001261748,0.00001008684,0.00004143894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001086212,0.00001883966,0.0002271974,0.00001732917,9.759399e-7,0.00003774782,0.0000103289,0.00001825125,0.9988039,0.00005424372,0.000007609269,0.0006950088],"study_design_scores_gemma":[0.00003290139,0.0003412962,0.008156821,0.000008475133,0.00001305835,0.0002638826,0.00004536752,0.0005026436,0.9889863,0.0000594064,0.001586681,0.000003243332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961976,0.001171833,0.00124715,0.00003003303,0.000020876,0.00001786658,0.0001277044,0.00003148591,0.001155438],"genre_scores_gemma":[0.995282,0.0008785129,0.001307996,0.00003847461,0.00001738716,0.00002614795,0.0002292664,0.00001709514,0.00220309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137525,"threshold_uncertainty_score":0.003805399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006826855937735281,"score_gpt":0.1884046406432951,"score_spread":0.1815777847055598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}