{"id":"W3097746180","doi":"10.1182/blood-2020-136607","title":"Investigational CD47-Blocker TTI-622 Shows Single-Agent Activity in Patients with Advanced Relapsed or Refractory Lymphoma: Update from the Ongoing First-in-Human Dose Escalation Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Medicine; Pharmacodynamics; Tolerability; Pharmacology; Adverse effect; Internal medicine; Refractory (planetary science); Lymphoma; Pharmacokinetics; Immune system; Immunology; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003312944,0.0005864828,0.002064745,0.0005119196,0.0001956958,0.001543554,0.0008070348,0.0008333447,0.001637314],"category_scores_gemma":[0.001618826,0.0002483681,0.001343663,0.0009168136,0.0004126181,0.0008548924,0.0002730786,0.00194057,0.0005304918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001044511,"about_ca_system_score_gemma":0.0007034537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420555,"about_ca_topic_score_gemma":0.001628858,"domain_scores_codex":[0.9995385,0.0001914919,0.00006355379,0.00005043856,0.00008784729,0.00006820467],"domain_scores_gemma":[0.9984512,0.000627381,0.0003326308,0.00008523509,0.0002684942,0.0002349144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0178754,0.002545463,0.01144738,0.003259161,0.001260871,0.0003381898,0.0003119916,0.00159599,0.02046618,0.0007025052,0.0113935,0.9288033],"study_design_scores_gemma":[0.05655998,0.1864133,0.1666287,0.003973222,0.006682565,0.006370613,0.0006181606,0.00515426,0.0241822,0.002456203,0.5407304,0.000230372],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5191367,0.4590508,0.002175466,0.004828605,0.0003823107,0.000773654,0.001796667,0.0003162317,0.01153959],"genre_scores_gemma":[0.729522,0.2463092,0.005057247,0.00835907,0.0007003086,0.001091634,0.005144179,0.0001571985,0.003659079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003312944,"threshold_uncertainty_score":0.01752073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970412747875858,"score_gpt":0.2233169555120087,"score_spread":0.2036128280332501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}