{"id":"W3097747347","doi":"10.1124/jpet.120.000196","title":"Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Glucocorticoid receptor; Roflumilast; Receptor; Prostanoid; Agonist; Reporter gene; Pharmacology; Gene expression; Phosphodiesterase; Calcitriol receptor; Immunology; Medicine; Chemistry; Biology; Endocrinology; Molecular biology; Internal medicine; COPD; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056449,0.0001848961,0.0003295298,0.0003023262,0.0001992806,0.0002824681,0.0001600814,0.0003296178,0.003493963],"category_scores_gemma":[0.0003332991,0.0001666375,0.0003769173,0.0003247094,0.000185081,0.0002377978,0.0001868094,0.0003618918,0.0007163979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001447965,"about_ca_system_score_gemma":0.0001876147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006598589,"about_ca_topic_score_gemma":0.0005153986,"domain_scores_codex":[0.9998333,0.00004351267,0.00001052503,0.00001755896,0.00002708688,0.00006795303],"domain_scores_gemma":[0.9998934,0.0000388897,0.00001535991,0.00001433938,0.00002566281,0.0000122988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001033355,0.0000554516,0.001495329,0.00006674384,0.00001320983,0.0002652529,0.00008058517,0.00005274397,0.9942775,0.0001002919,0.00008310667,0.00247647],"study_design_scores_gemma":[0.0001673663,0.002512214,0.1176661,0.00002497515,0.0001760029,0.001792056,0.0006890472,0.001170772,0.8693672,0.0002848594,0.006130018,0.00001941797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948968,0.002134239,0.0008373349,0.00007593559,0.00002823245,0.00003280614,0.0003373291,0.00001574239,0.00164151],"genre_scores_gemma":[0.9915112,0.001423966,0.001070084,0.00008073614,0.00004380903,0.0000767944,0.0008067206,0.00000776142,0.004978808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003493963,"threshold_uncertainty_score":0.01168847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672030846896911,"score_gpt":0.2973261008184072,"score_spread":0.2806057923494381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}