{"id":"W3097754840","doi":"10.1242/dev.190298","title":"E2A regulates neural ectoderm fate specification in human embryonic stem cells","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Biology; Ectoderm; Embryonic stem cell; Cell biology; Neural stem cell; Stem cell; Neural development; Embryogenesis; Developmental biology; Embryo; Neuroscience; Anatomy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388442,0.0001354719,0.0001211222,0.00004679437,0.00006771938,0.00002977621,0.0002450708,0.00008414792,0.00003252095],"category_scores_gemma":[0.000005117206,0.000136656,0.00003442919,0.0001329848,0.0000284299,0.000003731898,0.0001705146,0.0001033876,0.00009487742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005033939,"about_ca_system_score_gemma":0.00008482688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003624017,"about_ca_topic_score_gemma":0.00001979145,"domain_scores_codex":[0.9988047,0.00005783603,0.000242863,0.0004068841,0.0001962796,0.0002914348],"domain_scores_gemma":[0.9995925,0.000004886854,0.00005343947,0.0001977681,0.00004063261,0.0001107372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002866424,0.00003070334,0.001558863,0.00003336245,0.00001549302,0.00001153379,0.0002219144,0.0002712606,0.9936607,0.00001235087,0.001228938,0.002926163],"study_design_scores_gemma":[0.0003707461,0.0000529631,0.01608841,0.000009481707,0.000001548494,0.000002035273,0.00006111257,0.0003400954,0.9463591,0.000004012591,0.03654264,0.0001678736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977857,0.000233898,0.0001775443,0.0006947433,0.0000549357,0.0002562108,0.000002555177,0.0000167996,0.0007776287],"genre_scores_gemma":[0.9974643,0.00005316587,0.0003674358,0.000184788,0.00007044888,0.00002696648,0.0001023655,0.00002059187,0.001709953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04730166,"threshold_uncertainty_score":0.5572672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373696734869027,"score_gpt":0.2603521267699089,"score_spread":0.2266151594212187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}