{"id":"W3097754840","doi":"10.1242/dev.190298","title":"E2A regulates neural ectoderm fate specification in human embryonic stem cells","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Biology; Ectoderm; Embryonic stem cell; Cell biology; Neural stem cell; Stem cell; Neural development; Embryogenesis; Developmental biology; Embryo; Neuroscience; Anatomy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006720104,0.0002047963,0.0001106227,0.0001585435,0.0001455448,0.0003137926,0.00007362749,0.000108925,0.001094329],"category_scores_gemma":[0.00006025558,0.0001164891,0.0001295193,0.00009971785,0.000140464,0.0001181062,0.0001939049,0.000161484,0.0004357446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962719,"about_ca_system_score_gemma":0.0001778647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009022644,"about_ca_topic_score_gemma":0.001504588,"domain_scores_codex":[0.9999447,0.00001044128,0.000006703793,0.00001333632,0.00001490027,0.000009897279],"domain_scores_gemma":[0.9999772,0.000003646079,0.00000564425,0.000003089027,0.000003450893,0.000007026969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005317021,0.00001061708,0.000512943,0.0000172948,0.000003824296,0.0000649361,0.000009122988,0.0000552401,0.9980776,0.00008770869,0.00003816596,0.001069342],"study_design_scores_gemma":[0.00001081926,0.00006036464,0.02529356,0.000006611003,0.00001398349,0.0003274248,0.00004742786,0.0007653027,0.9689856,0.00009889812,0.004385961,0.00000402716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895775,0.004055694,0.002380569,0.00008933285,0.00002294949,0.00001793677,0.0007238104,0.00007555611,0.003056549],"genre_scores_gemma":[0.99248,0.001538477,0.0008815639,0.00004331323,0.000004395079,0.00001340381,0.0006671298,0.00001626537,0.004355414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094329,"threshold_uncertainty_score":0.003660917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373696734869027,"score_gpt":0.2603521267699089,"score_spread":0.2266151594212187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}