{"id":"W3097778032","doi":"10.1182/blood-2020-137258","title":"Double-Hit Signature with <i>TP53</i> Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-Cell Lymphoma Treated with R-CHOP","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; CancerCare Manitoba","funders":"","keywords":"Diffuse large B-cell lymphoma; BCL6; Germinal center; Lymphoma; Fluorescence in situ hybridization; Biology; Cancer research; Comparative genomic hybridization; Immunophenotyping; Oncology; Internal medicine; Pathology; Medicine; B cell; Immunology; Genetics; Gene; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105315,0.0002440438,0.0002683357,0.0005919148,0.0002212058,0.0003596279,0.0002310764,0.0003045805,0.0007232897],"category_scores_gemma":[0.0006880308,0.0001232659,0.00017038,0.0004224791,0.0002868492,0.0002292473,0.0002588103,0.0003025165,0.000141752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001727782,"about_ca_system_score_gemma":0.000140671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006955731,"about_ca_topic_score_gemma":0.0009637094,"domain_scores_codex":[0.9998759,0.00002326594,0.00001316279,0.00003273104,0.00002551061,0.00002941211],"domain_scores_gemma":[0.9995554,0.00009624534,0.0001761038,0.0000273022,0.00003457172,0.0001103051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001333704,0.00001101077,0.9967791,0.000004084849,0.00001270298,0.000278651,0.00001871967,0.00005190114,0.001524378,0.000004125529,0.00003096807,0.001150817],"study_design_scores_gemma":[0.00000763151,0.0001185574,0.9958937,0.000002473203,0.0000310119,0.002946099,0.0000820201,0.0003865151,0.0003725711,0.0000206991,0.0001364854,0.000002171208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996334,0.0001431777,0.0000513213,0.00001426804,0.00000133635,0.000002220795,0.00003512149,0.000002635554,0.0001165317],"genre_scores_gemma":[0.9998062,0.00003442879,0.00004829023,0.000007551478,0.000003823433,0.00000130658,0.0000797311,8.006003e-7,0.00001785658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007232897,"threshold_uncertainty_score":0.00241971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007823083668783001,"score_gpt":0.1955919838357955,"score_spread":0.1877689001670125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}