{"id":"W3097788036","doi":"10.1016/j.cell.2020.09.062","title":"M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Gobierno de Aragón; Ministerio de Ciencia e Innovación; Molson Foundation; Canadian Institutes of Health Research; McGill University Health Centre; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Myelopoiesis; Biology; Immunity; Haematopoiesis; Innate immune system; Immunology; Stem cell; Immune system; Myeloid; Bone marrow; Lymphopoiesis; Mycobacterium tuberculosis; Progenitor cell; Cell biology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395408,0.0002686567,0.0001829588,0.0001559377,0.00008071971,0.0002160845,0.0001099364,0.0002404841,0.0009465655],"category_scores_gemma":[0.00008415904,0.00008202696,0.00009930734,0.00006350299,0.0003042453,0.0001130084,0.0001733468,0.0005798684,0.0002239822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215954,"about_ca_system_score_gemma":0.0001162812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00010009,"about_ca_topic_score_gemma":0.000272036,"domain_scores_codex":[0.9998782,0.00003226032,0.00001069425,0.00001932917,0.0000275785,0.00003202428],"domain_scores_gemma":[0.9999236,0.00001214198,0.00002507011,0.00001050123,0.000004861625,0.00002381708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008257041,0.00002906156,0.0002334862,0.00002081183,0.000001694138,0.00002907009,0.00001592534,0.0000371137,0.9979091,0.0001124385,0.00002541708,0.001503366],"study_design_scores_gemma":[0.00004187102,0.001048225,0.008134089,0.00002125091,0.00001176802,0.0002618734,0.00006372791,0.0008075351,0.9863656,0.0001853638,0.00305537,0.000003500672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960269,0.001075628,0.001571147,0.00010306,0.00003020815,0.00002234367,0.00009647425,0.00008293813,0.0009913533],"genre_scores_gemma":[0.9975434,0.0004402813,0.000850736,0.00006603073,0.000009856803,0.00002222439,0.00007431296,0.000008667479,0.0009844544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009465655,"threshold_uncertainty_score":0.003166556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815823284998874,"score_gpt":0.2295570785872579,"score_spread":0.2113988457372692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}