{"id":"W3097788036","doi":"10.1016/j.cell.2020.09.062","title":"M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Gobierno de Aragón; Ministerio de Ciencia e Innovación; Molson Foundation; Canadian Institutes of Health Research; McGill University Health Centre; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Myelopoiesis; Biology; Immunity; Haematopoiesis; Innate immune system; Immunology; Stem cell; Immune system; Myeloid; Bone marrow; Lymphopoiesis; Mycobacterium tuberculosis; Progenitor cell; Cell biology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001816168,0.000188503,0.000289849,0.00006473232,0.0002522148,0.00003540215,0.0002148096,0.0001726361,0.0004348542],"category_scores_gemma":[0.0000330538,0.000174004,0.0001137449,0.0002766467,0.00005962822,0.00005707623,0.0001819862,0.0002403109,0.0008554216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002297409,"about_ca_system_score_gemma":0.00003640699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005814083,"about_ca_topic_score_gemma":0.000004519952,"domain_scores_codex":[0.9988292,0.0002010982,0.0002739624,0.0003275377,0.00002873839,0.0003394949],"domain_scores_gemma":[0.9992864,0.0001766378,0.00006169776,0.000338545,0.00005819611,0.00007848725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854925,0.0001842563,0.0002455958,0.0001080383,0.0001133198,0.000007848651,0.008047408,0.000005753942,0.9657446,0.00009888599,0.009015758,0.01614302],"study_design_scores_gemma":[0.001459828,0.0006618294,0.003960154,0.00002542131,0.0001035655,0.00003523865,0.004335207,0.00001845684,0.8698076,0.00002866851,0.1191838,0.0003802306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902646,0.003180785,0.0001747079,0.004549555,0.0001916863,0.0004066313,0.00002667048,0.0001549676,0.0010504],"genre_scores_gemma":[0.995477,0.0001644836,0.0001568423,0.0008046857,0.00001789035,0.0000357053,0.0000213267,0.00002417612,0.003297936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.110168,"threshold_uncertainty_score":0.9999225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815823284998874,"score_gpt":0.2295570785872579,"score_spread":0.2113988457372692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}