{"id":"W3097795751","doi":"10.1182/blood-2020-138822","title":"Preliminary Results from a Phase 1 Study of Cfi-400495, a PLK4 Inhibitor, in Patients with Acute Myeloid Leukemia and High Risk MDS","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre; McMaster University; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Myeloid leukemia; Pharmacodynamics; Induction chemotherapy; Oncology; Chemotherapy regimen; Leukemia; Phases of clinical research; Chemotherapy; Gastroenterology; Adverse effect; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001645351,0.001279033,0.001426386,0.0003430412,0.0003883783,0.0005963607,0.0005829611,0.0009124867,0.003355315],"category_scores_gemma":[0.001256185,0.0004168452,0.0008415018,0.0002947356,0.0005310296,0.0005878978,0.0002921194,0.002323659,0.000614839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005710881,"about_ca_system_score_gemma":0.001086821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007429067,"about_ca_topic_score_gemma":0.002277885,"domain_scores_codex":[0.9995461,0.0002490479,0.00002787193,0.00006091228,0.0000417436,0.00007428355],"domain_scores_gemma":[0.9991959,0.000246931,0.0001258843,0.00006730936,0.0000618141,0.0003022001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5000293,0.1036532,0.02767222,0.001320305,0.001799841,0.0009744588,0.0007622553,0.005469992,0.1302334,0.0004309247,0.007947304,0.2197069],"study_design_scores_gemma":[0.3121987,0.6276035,0.04395961,0.00005324664,0.0007261889,0.0009177694,0.00008898054,0.001279923,0.008308311,0.0003432432,0.004478827,0.00004165815],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905216,0.002145001,0.0009925349,0.0006422004,0.00005893817,0.002381614,0.001043043,0.0001009615,0.002114264],"genre_scores_gemma":[0.9896422,0.001289811,0.002398378,0.0008418521,0.0001178682,0.001684506,0.002174287,0.00002355907,0.001827575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003355315,"threshold_uncertainty_score":0.01122469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271665486061108,"score_gpt":0.2596851803734144,"score_spread":0.2469685255128033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}