{"id":"W3097807353","doi":"10.1097/cmr.0000000000000701","title":"Transcriptional analysis of metastatic uveal melanoma survival nominates NRP1 as a therapeutic target","year":2020,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Exelixis; Melanoma Research Alliance; U.S. Department of Defense","keywords":"Melanoma; Cancer research; Medicine; PI3K/AKT/mTOR pathway; Metastasis; Transcriptome; Mucosal melanoma; Oncology; Cancer; Biology; Internal medicine; Gene; Signal transduction; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079412,0.0001626254,0.0002423978,0.0002732518,0.0001807868,0.0003300146,0.00008154047,0.0001363585,0.001514156],"category_scores_gemma":[0.0002140589,0.00007109848,0.000220724,0.0002911018,0.0001520752,0.0001177912,0.00013234,0.0003935013,0.0002551278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224535,"about_ca_system_score_gemma":0.0002663323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006826766,"about_ca_topic_score_gemma":0.001592128,"domain_scores_codex":[0.999851,0.0000208087,0.000007080149,0.00003750181,0.00005458141,0.00002909476],"domain_scores_gemma":[0.9999025,0.00002207795,0.0000257471,0.000007905432,0.00002182162,0.00001996736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004204044,0.00003683866,0.004460986,0.00005998752,0.00001146721,0.00005326813,0.00004021454,0.0001500134,0.9907132,0.00007661348,0.0001231378,0.003853823],"study_design_scores_gemma":[0.0000610059,0.002126305,0.2237275,0.00003992581,0.0001105213,0.0008956009,0.0004638473,0.005302003,0.7571353,0.0003470183,0.009772614,0.00001834687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866788,0.003271952,0.003803432,0.0002719378,0.0000382052,0.00006139686,0.003697043,0.00007877193,0.002098477],"genre_scores_gemma":[0.9894584,0.00133405,0.003381839,0.0001545834,0.00001899082,0.00009157872,0.003269142,0.00002116005,0.002270274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514156,"threshold_uncertainty_score":0.005065382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281101208113093,"score_gpt":0.4077181227330979,"score_spread":0.2796080019217886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}