{"id":"W3097824528","doi":"10.1182/blood-2020-142723","title":"Totality of Scientific Evidence in the Development of ABP 798, a Biosimilar to Rituximab","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital","funders":"","keywords":"Medicine; Rituximab; Oncology; Pharmacology; Clinical trial; In vivo; Pharmacodynamics; Internal medicine; Biosimilar; Lymphoma; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001085828,0.00008557347,0.0002464485,0.00005081098,0.00005733496,0.000008644877,0.0003698536,0.00009591501,0.0001235171],"category_scores_gemma":[0.0005048529,0.00005502314,0.00006027978,0.0005007845,0.0002241222,0.00002862246,0.0001221,0.0001282388,0.00002905017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005246066,"about_ca_system_score_gemma":0.00008941478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007120745,"about_ca_topic_score_gemma":0.00002324688,"domain_scores_codex":[0.998911,0.0002285447,0.0003844131,0.0002349548,0.00006337123,0.0001776671],"domain_scores_gemma":[0.9994216,0.0001960987,0.00007452182,0.0002226252,0.000062814,0.00002235298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009757059,0.0009076634,0.006741605,0.0001044487,0.00007553676,0.000002401565,0.003599601,3.102218e-7,0.9829963,0.0002892489,0.0007330825,0.004452217],"study_design_scores_gemma":[0.0008382592,0.0001836218,0.02982809,0.0001001253,0.00005374408,0.0000033098,0.0003109133,0.000001649085,0.961112,0.00006805133,0.007408727,0.00009152649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939722,0.001288007,0.0002534126,0.003795618,0.00009794842,0.0002692673,0.0000204653,0.000008683876,0.0002943862],"genre_scores_gemma":[0.9920903,0.000005458314,0.007253767,0.0005937756,0.000007162763,0.000008900688,0.000002149404,0.000002988905,0.00003545792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02308648,"threshold_uncertainty_score":0.2243779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110579354271101,"score_gpt":0.3254139175251707,"score_spread":0.2143559820980607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}