{"id":"W3097825419","doi":"10.1093/biolre/ioaa206","title":"Dynamics in the expression of epigenetic modifiers and histone modifications in perinatal rat germ cells during de novo DNA methylation†","year":2020,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Armand-Frappier Foundation","keywords":"Biology; Histone methyltransferase; Epigenomics; Histone methylation; DNA methylation; Epigenetics; Histone; Histone code; Reprogramming; Cancer epigenetics; EZH2; Epigenetic regulation of neurogenesis; Histone H2A; Molecular biology; Cell biology; Genetics; Gene expression; DNA; Cell; Gene; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273252,0.00007471019,0.0001160929,0.00006260435,0.00003181249,0.000002739657,0.000087763,0.0001192579,0.000001654343],"category_scores_gemma":[0.0001426505,0.00006677789,0.00002783882,0.0001272611,0.0001340556,0.000004703431,0.00003730207,0.00007122408,1.891978e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525413,"about_ca_system_score_gemma":0.00002814098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003647901,"about_ca_topic_score_gemma":0.00003561471,"domain_scores_codex":[0.9991358,0.0001496672,0.0002545369,0.0003148023,0.00004673459,0.00009845049],"domain_scores_gemma":[0.9995473,0.00001543983,0.0001337387,0.0002385402,0.00004347746,0.00002151549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005755176,0.00003352337,0.007682458,0.00003584853,0.000003411927,2.976727e-7,0.0004364229,0.001593882,0.988077,0.00009845285,0.000001712483,0.001979371],"study_design_scores_gemma":[0.0002692803,0.0001345264,0.03131927,0.000006273508,0.000005001771,0.000002318676,0.0002563764,0.0005802022,0.966935,0.000249973,0.0001779988,0.00006374685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922869,0.003708735,0.00307567,0.0006208693,0.00005967684,0.000181124,0.00000863164,0.000002787928,0.00005565795],"genre_scores_gemma":[0.9976593,0.001080158,0.001111068,0.000007011144,0.00005604218,0.0000150164,0.00004791832,0.000006527363,0.00001693107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02363681,"threshold_uncertainty_score":0.2723123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675137753651895,"score_gpt":0.2728227896206262,"score_spread":0.2560714120841072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}