{"id":"W3097833619","doi":"10.1111/febs.15622","title":"Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus <i>Candida albicans</i>","year":2020,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Roy J. Carver Charitable Trust","keywords":"Candida albicans; NAD+ kinase; Biology; Sirtuin; Corpus albicans; Cytotoxicity; Nicotinamide; Intracellular; Metabolome; Sirtuin 1; Microbiology; Acetylation; Histone deacetylase; Biochemistry; Metabolite; Histone; In vitro; Downregulation and upregulation; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166556,0.000525218,0.0003703992,0.0002669972,0.0002094978,0.000489827,0.000575518,0.00055424,0.001299497],"category_scores_gemma":[0.0001408287,0.000153498,0.0005368341,0.0001347859,0.0002611557,0.000249146,0.0002252552,0.0009022179,0.0003223148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339114,"about_ca_system_score_gemma":0.0003616385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006197967,"about_ca_topic_score_gemma":0.0008780994,"domain_scores_codex":[0.9998821,0.00001353098,0.00001177107,0.00002535727,0.00003171434,0.00003545969],"domain_scores_gemma":[0.9999007,0.00001151862,0.00002853844,0.00001466572,0.00002338707,0.00002121926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001700718,0.0001110983,0.0001159283,0.000143969,0.00001236388,0.00002961466,0.00000708884,0.0001299902,0.9941902,0.0001863737,0.0001583376,0.004745037],"study_design_scores_gemma":[0.00006488425,0.0009153345,0.00280028,0.00002046853,0.00003242185,0.0001386369,0.00002031979,0.0007845363,0.9913285,0.0001131779,0.003771962,0.000009587245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501009,0.01507061,0.02155056,0.001391912,0.0003485697,0.0005620779,0.001822205,0.001398835,0.007754348],"genre_scores_gemma":[0.9757027,0.005168064,0.01359194,0.0006521731,0.00005388372,0.0003312834,0.0007709728,0.00005521995,0.003673867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299497,"threshold_uncertainty_score":0.004347265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972460150122128,"score_gpt":0.3158483071214511,"score_spread":0.2761237056202298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}